Results 241 to 250 of about 13,089,035 (315)

MSF-HierGNN: a multi-source substructure-fusion hierarchical GNN method and web server to predict molecular property for drug design. [PDF]

Brief Bioinform
Xiao M, Xiao Y, Wu Y, You Y, Liu X, Van Thanh H, Zhang L.   +6 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Kinetic Analysis of Irreversible Covalent Enzyme Inhibitors and Its Use in Drug Design. [PDF]

Int J Mol Sci
Chaudière J.
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Accelerated Combinatorial Drug Design for Human Immunodeficiency Virus Resistance through Seeded Multisite λ-Dynamics. [PDF]

J Chem Theory Comput
Bowling PE, Vilseck JZ, Brooks CL.
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Modulator-induced conformational changes in complement C5, implications for function and drug design. [PDF]

Front Immunol
Zhivnov A, Ottochian C, El-Bouri K, Francis R, Campbell R, Macpherson A, Wells S, van den Elsen JM.   +7 more
europepmc   +1 more source

Thieno[3,2-<i>d</i>]pyrimidines in Anticancer Drug Discovery: Recent Advances in Drug Design and Molecular Targets. [PDF]

Int J Mol Sci
Buronov A, Gaybullaev S, Murtazaeva Z, Ruzieva F, Khushnazarov Z, Turgunov D, Nasrullaev A, Kuryazov R, Takhirov Y, Tursunov F, Kushatov T, Dushamov D, Matmuratov S, Nurullaeva N, Shodikulova A, Khalikov K, Kholmurodova D, Numonov S, Niu C, Ji Y, Zhao J, Ge Z, Bozorov K.   +22 more
europepmc   +1 more source