Results 261 to 270 of about 13,089,035 (315)
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Clinical Pharmacology & Therapeutics, 2017
This “Designer Drugs 2.0” issue of Clinical Pharmacology & Therapeutics focuses on novel psychoactive substances, primarily cannabinoids and cathinones, and the repurposing of established psychoactive compounds (e.g., modafinil, psilocybin, lysergic acid diethylamide, and 3,4‐methylenedioxymethamphetamine) that simultaneously offer new ...
M A, Huestis, R F, Tyndale
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This “Designer Drugs 2.0” issue of Clinical Pharmacology & Therapeutics focuses on novel psychoactive substances, primarily cannabinoids and cathinones, and the repurposing of established psychoactive compounds (e.g., modafinil, psilocybin, lysergic acid diethylamide, and 3,4‐methylenedioxymethamphetamine) that simultaneously offer new ...
M A, Huestis, R F, Tyndale
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Biochemical Pharmacology, 1975
Abstract Parachor has been used extensively in physical organic chemistry for structure determination. It has rarely been used as a parameter for the correlation of structure and biological activity. We have reexamined the parachor concept for structure-activity correlations of some closely related analogs.
P, Ahmad, C A, Fyfe, A, Mellors
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Abstract Parachor has been used extensively in physical organic chemistry for structure determination. It has rarely been used as a parameter for the correlation of structure and biological activity. We have reexamined the parachor concept for structure-activity correlations of some closely related analogs.
P, Ahmad, C A, Fyfe, A, Mellors
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Bioactivation of Drugs: Risk and Drug Design
Annual Review of Pharmacology and Toxicology, 2011Bioactivation through drug metabolism is frequently suspected as an initiating event in many drug toxicities. The CYP450 and peroxidase enzyme systems are generally considered the most important groups of enzymes involved in bioactivation, producing either electrophilic or radical metabolites. Drug design efforts routinely consider these factors, and a
John S, Walsh, Gerald T, Miwa
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Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology,and Health Informatics, 2017
Computational drug design is highly dependent on the model being used for docking and fitting of structure. Those models are derived mainly from X-ray structures and hopefully represent the physiologically relevant form of the protein in solution.
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Computational drug design is highly dependent on the model being used for docking and fitting of structure. Those models are derived mainly from X-ray structures and hopefully represent the physiologically relevant form of the protein in solution.
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Dental Clinics of North America, 1982
The important tasks in developing an emergency kit have been reviewed. 1. Select the right equipment to handle life-threatening emergencies. Make the selections based on individual effective and efficient use. Select drugs and equipment in consultation with the closest, most available and willing physician, hospital, emergency service, or community ...
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The important tasks in developing an emergency kit have been reviewed. 1. Select the right equipment to handle life-threatening emergencies. Make the selections based on individual effective and efficient use. Select drugs and equipment in consultation with the closest, most available and willing physician, hospital, emergency service, or community ...
openaire +2 more sources
Clinical Pharmacology & Therapeutics, 2016
The concepts behind current “designer drugs” are not new. For several centuries, chemical synthesis has made drugs more specific and more selective. However, headline designer drugs now are different and a serious public health problem because they are illicit unregulated chemical knockoffs of approved psychoactive stimulant, sedative, or perception ...
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The concepts behind current “designer drugs” are not new. For several centuries, chemical synthesis has made drugs more specific and more selective. However, headline designer drugs now are different and a serious public health problem because they are illicit unregulated chemical knockoffs of approved psychoactive stimulant, sedative, or perception ...
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Medical Toxicology, 1988
'Designer drugs' are substances intended for recreational use which are derivatives of approved drugs so as to circumvent existing legal restrictions. The term as popularised by the lay press lacks precision. Contrary to the popular belief that 'designer drugs' are original creations, the majority of these agents are 'borrowed' from legitimate ...
J F, Buchanan, C R, Brown
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'Designer drugs' are substances intended for recreational use which are derivatives of approved drugs so as to circumvent existing legal restrictions. The term as popularised by the lay press lacks precision. Contrary to the popular belief that 'designer drugs' are original creations, the majority of these agents are 'borrowed' from legitimate ...
J F, Buchanan, C R, Brown
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Bioanalysis of New Designer Drugs
Bioanalysis, 2010Since the late 1990s the illicit drug market has undergone considerable change: along with the traditional drugs of abuse that still dominate, more than 100 psychotropic substances designed to bypass controlled substances legislation have appeared and led to intoxications and fatalities.
Wohlfarth, Ariane, Weinmann, Wolfgang
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Antisense Oligonucleotide Drug Design
Current Pharmaceutical Design, 2004Maneuvering single gene expression is not only an optimal way to study gene function but also an ambitious goal, which will lead to the treatment of a variety of human diseases whose main pathogenetic event is a genetic alteration. The recent efforts focusing on the genome project have led to array based, high throughput, gene expression analysis ...
SCHIAVONE, NICOLA +3 more
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Immunoinformatics in Drug Designing
Immunoinformatics is a sub-branch of immunology that was risen from the huge amount of data generated from tons of genomic and proteomic projects dealing with the host- pathogen interactions in the need of analyzing these data. Immunoinformatics primarily focuses on predicting the algorithmic mapping of epitopes, thus reducing both cost and time ...Das, Anwesha +3 more
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