Results 251 to 260 of about 13,089,035 (315)
The Role of Hydrogen Bond Donors and Intramolecular Hydrogen Bonding in Modulating Blood-Brain Barrier Permeability: Implications for CNS Drug Design. [PDF]
MoleculesNovás M +4 more
europepmc +1 more source
Multi-Property De Novo Drug Design Using Deep Learning-Based Knowledge Distillation and Reinforcement Learning. [PDF]
Int J Mol SciWang L +9 more
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Benchmarking Molecular Mutation Operators for Evolutionary Drug Design. [PDF]
Int J Mol SciAcosta Murillo R +2 more
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Computer-Aided Drug Design for Type 2 Diabetes-Related Enzymes: SILCS-Based Fragment Mapping, Pharmacophore Modeling, and Virtual Screening. [PDF]
J Chem Inf ModelMohammadi E, Lemkul JA.
europepmc +1 more source
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Emergency Medicine Clinics of North America, 2021
In recent years, there has been an emergence of numerous novel drugs. Such toxicity may occur in both adolescents and adults. This article discusses the opioid epidemic and several emerging opioids, including buprenorphine, loperamide, fentanyl, fentanyl derivatives, and others.
Michael, Levine, Frank, Lovecchio
openaire +2 more sources
In recent years, there has been an emergence of numerous novel drugs. Such toxicity may occur in both adolescents and adults. This article discusses the opioid epidemic and several emerging opioids, including buprenorphine, loperamide, fentanyl, fentanyl derivatives, and others.
Michael, Levine, Frank, Lovecchio
openaire +2 more sources
Archives of Biochemistry and Biophysics, 2017
The use of NMR as a tool to determine 3 dimensional protein solution structures, once a darling of the pharmaceutical industry, has largely given way to study of the interaction of prospective drugs with macromolecular targets. Many of these approaches involve ligand-centered studies, which have the advantage of speed and efficiency, but there are also
Mary J, Harner +3 more
openaire +2 more sources
The use of NMR as a tool to determine 3 dimensional protein solution structures, once a darling of the pharmaceutical industry, has largely given way to study of the interaction of prospective drugs with macromolecular targets. Many of these approaches involve ligand-centered studies, which have the advantage of speed and efficiency, but there are also
Mary J, Harner +3 more
openaire +2 more sources
European Journal of Pharmacology, 2009
In this article, current knowledge of drug design is reviewed and an approach of rational drug design is presented. The process of drug development is challenging, expensive, and time consuming, although this process has been accelerated due to the development of computational tools and methodologies.
Soma, Mandal +2 more
openaire +2 more sources
In this article, current knowledge of drug design is reviewed and an approach of rational drug design is presented. The process of drug development is challenging, expensive, and time consuming, although this process has been accelerated due to the development of computational tools and methodologies.
Soma, Mandal +2 more
openaire +2 more sources
Current Pharmaceutical Design, 2003
The following review outlines the physiological outcome of VIP and VIP gene manipulations. Previously, we reviewed the various VIP receptors associated with biological functions ranging from growth regulation, sexual function, bronchodilation, vasodilation and immune interactions to neurotrophism. VIP-based drug design is discussed below.
Illana, Gozes, Sharon, Furman
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The following review outlines the physiological outcome of VIP and VIP gene manipulations. Previously, we reviewed the various VIP receptors associated with biological functions ranging from growth regulation, sexual function, bronchodilation, vasodilation and immune interactions to neurotrophism. VIP-based drug design is discussed below.
Illana, Gozes, Sharon, Furman
openaire +2 more sources
Emergency Medicine Clinics of North America, 1990
Despite the increasing use of other illicit drugs, opioid abuse, overdose, and the ensuing medical complications continue to pose management challenges for the emergency physician. Heroin use is increasing as abusers of cocaine seek a drug to prolong cocaine's effects while blunting the postcocaine depression.
M, Ford, R S, Hoffman, L R, Goldfrank
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Despite the increasing use of other illicit drugs, opioid abuse, overdose, and the ensuing medical complications continue to pose management challenges for the emergency physician. Heroin use is increasing as abusers of cocaine seek a drug to prolong cocaine's effects while blunting the postcocaine depression.
M, Ford, R S, Hoffman, L R, Goldfrank
openaire +2 more sources