Results 261 to 270 of about 17,208,238 (361)

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Improved structure of mouse gasdermin D: a new blueprint for structure-based drug design. [PDF]

Acta Crystallogr F Struct Biol Commun
De Colibus L, Ludzia P, Biasutto A, Pica A, Hopper JTS, Jazayeri A, Dürr KL.   +6 more
europepmc   +1 more source

Typical design of SMC drug distribution campaign.

Olusola Bukola Oresanya (22394653), Olujide Arije (7862927), Jesujuwonlo Fadipe (22394656), Kunle Rotimi (17897998), Abimbola Phillips (12292942), Kolawole Maxwell (3455870), Emmanuel Shekarau (5413520), Nneka Onwu (22394659), Eva S. Bazant (22057598)   +8 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Advancing in silico drug design with Bayesian refinement of AlphaFold models

Sen S, Hoff SE, Morozova TI, Schnapka V, Bonomi M.   +4 more
europepmc   +1 more source

MolSnapper: Conditioning Diffusion for Structure-Based Drug Design. [PDF]

J Chem Inf Model
Ziv Y, Imrie F, Marsden B, Deane CM.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Toxicity assessment of doxycycline-aided artificial intelligence-assisted drug design targeting candidate 16S rRNA methyltransferase gene. [PDF]

BMC Pharmacol Toxicol
Mubeen H, Rafiq N, Khan M, Jabeen S, Shoaib MW.   +4 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Structural bioinformatics for rational drug design. [PDF]

Res Pract Thromb Haemost
Mozaffari S, Moen A, Ng CY, Nicolaes GAF, Wichapong K.   +4 more
europepmc   +1 more source