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Strategies in the Rational Drug Design
Current Medicinal Chemistry, 2011Rational design is applied in the discovery of novel lead drugs. Its rapid development is mainly attributed to the tremendous advancements in the computer science, statistics, molecular biology, biophysics, biochemistry, medicinal chemistry, pharmacokinetics and pharmacodynamics experienced in the last few decades.
T. Mavromoustakos +6 more
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Bioanalysis of New Designer Drugs
Bioanalysis, 2010Since the late 1990s the illicit drug market has undergone considerable change: along with the traditional drugs of abuse that still dominate, more than 100 psychotropic substances designed to bypass controlled substances legislation have appeared and led to intoxications and fatalities.
Wohlfarth, Ariane, Weinmann, Wolfgang
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Protein Crystallography and Drug Design
1987Safe and reliable drugs belong to the most impressive scientific achievements of mankind. One would only wish that there were more drugs such as penicillin which allows recovery from serious and painful bacterial infections in a matter of days, if not hours.
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Drug Design Issues on the Cell BE
2008Structure alignment prediction between proteins (protein docking) is crucial for drug design, and a challenging problem for bioinformatics, pharmaceutics, and current and future processors due to it is a very time consuming process. Here, we analyze a well known protein docking application in the Bioinformatic field, Fourier Transform Docking (FTDock),
Servat H. +4 more
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