Results 41 to 50 of about 3,066,996 (254)

Multi-drug infusion control using model reference adaptive algorithm [PDF]

, 2011
Control of physiological states such as mean arterial pressure (MAP) has been successfully achieved using single drug by different control algorithms. Multi-drug delivery demonstrates a significantly challenging task as compared to control with a single ...
Enbiya, Saleh, Hossain, Alamgir, Mahieddine, Fatima   +2 more
core   +1 more source

2D-QSAR driven design, molecular docking, molecular dynamics simulation and MM/GBSA studies on quinazoline derivatives for development of VEGFR-2 inhibitors

Discover Chemistry
Various in silico approaches were utilized to design quinazoline derivatives as anticancer agents targeting VEGFR-2. Six 2D-QSAR models were generated via Monte Carlo optimization method of CORALSEA software.
Mayank Kashyap, Saurabh Gupta, Yogita Bansal, Gulshan Bansal   +3 more
doaj   +1 more source

Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing

Scientific Reports, 2021
A major class of bispecific antibodies (BsAbs) utilizes heterodimeric Fc to produce the native immunoglobulin G (IgG) structure. Because appropriate pairing of heavy and light chains is required, the design of BsAbs produced through recombination or ...
Hiroki Akiba, Tomoko Ise, Satoshi Nagata, Haruhiko Kamada, Hiroaki Ohno, Kouhei Tsumoto   +5 more
doaj   +1 more source

Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase [PDF]

, 2017
Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics.
Gallant, Joseph P.
core   +1 more source

Angiogenic signaling pathways and anti-angiogenic therapy for cancer

Signal Transduction and Targeted Therapy, 2023
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process regulated by various pro- and anti-angiogenic molecules, which plays a crucial role in tumor growth, invasion, and metastasis.
Zhen-Ling Liu, Huan-Huan Chen, Li-Li Zheng, Li-Ping Sun, Lei Shi   +4 more
doaj   +1 more source

Conformational decoupling in acid-sensing ion channels uncovers mechanism and stoichiometry of PcTx1-mediated inhibition

eLife, 2022
Acid-sensing ion channels (ASICs) are trimeric proton-gated cation channels involved in fast synaptic transmission. Pharmacological inhibition of ASIC1a reduces neurotoxicity and stroke infarct volumes, with the cysteine knot toxin psalmotoxin-1 (PcTx1 ...
Stephanie A Heusser, Christian B Borg, Janne M Colding, Stephan A Pless   +3 more
doaj   +1 more source

A theoretical framework for estimation of AUCs in complete and incomplete sampling designs. [PDF]

, 2009
Nonclinical in vivo animal studies have to be completed before starting clinical studies of the pharmacokinetic behavior of a drug in humans. The drug exposure in animal studies is often measured by the area under the concentration versus time curve (AUC)
Jaki, Thomas, Wolfsegger, Martin J.
core   +1 more source

The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design [PDF]

, 2023
Grazia Raffaella Tundo, Giuseppe Grasso, Marco Persico, О. В. Ткачук, Francesco Bellia, Alessio Bocedi, Stefano Marini, Mariacristina Parravano, Grazia Graziani, Caterina Fattorusso, Diego Sbardella   +10 more
openalex   +1 more source

In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates.

, 2014
A sequence of computational methods was used for predicting novel drug targets against drug resistant malaria parasite Plasmodium falciparum. Comparative genomics, orthologous protein analysis among same and other malaria parasites and protein-protein ...
Altschul, Andrews, Anishetty, Arama, Berman, Bernstein, Bhasin, Boeckmann, Chang, Chawley, Chen, Colovos, Corpet, David Charles Warhurst, Eisenberg, Finn, Franceschini, Ghosh, Irwin, Irwin, Kanehisa, Konc, Krogh, Kushwaha, Larsen, Laskowski, Ludin, Miller, Morris, Mrutyunjay Suar, Mulder, Pieper, Pierleoni, Pontius, Rajani Kanta Mahapatra, Sali, Subhashree Rout, Sun, Tam, von Mering, Wallner, Wiederstein, World Health Organization, Yang, Yeh, Zhexin   +45 more
core   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
A Debrabant, A Dube, A Mehta, A Mukherjee, AB Sidhu, AC Coelho, AH Fairlamb, Ashutosh, B Gourbal, B Vergnes, Basudha Khanal, BJ Mookerjee, C Brochu, C Dumas, CS Ferreira, D Legare, DM Weinreich, F Chappuis, F Frezard, G Mandal, Graham H. Coombs, H Denton, H Shim, Hideo Imamura, HW Murray, J Alvar, J Hellemans, J Mikus, J Tovar, JC Mottram, JC Munday, Jean-Claude Dujardin, JM Kelly, K Ait-Oudhia, K Grondin, KC Carter, Kirstyn Brunker, KW Tintaya, L Flohe, M Maharjan, M Samant, M Vanaerschot, Manu Vanaerschot, MK Mittal, ML Cunningham, MR Ariyanayagam, MR Perry, N Beerenwinkel, N Singh, N Van Meirvenne, P Baiocco, PJ Alcolea, PR Romao, R Hadighi, R Lira, R Mukhopadhyay, R Rojas, R Singh, RA Williams, RI da Luz, RL Krauth-Siegel, RL Krauth-Siegel, S Borrell, S Decuypere, S Dey, S Gagneux, S Mandal, S Muller, S Rais, S Rijal, S Sundar, S Wyllie, S Wyllie, S Yan, S Yan, Saskia Decuypere, Suman Rijal, Sylke Müller, T Downing, T Downing, T Laurent, T Nozaki, Timothy G. Geary, V Adaui, V Yardley, Y Zhou   +85 more
core   +4 more sources