Results 61 to 70 of about 2,938,349 (358)
Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method
Scientific Reports, 2017 Virtual screening offers an efficient alternative to high-throughput screening in the identification of pharmacological tools and lead compounds. Virtual screening is typically based on the matching of target structures or ligand pharmacophores to ...
Ida Osborn Frandsen +7 more
doaj +1 more source
A pair of new enantiomers of xanthones from the stems and leaves of Cratoxylum cochinchinense
Chinese Medicine, 2019 Background The simple and caged xanthones from Clusiaceae showed significant antineoplastic activity. This study aims to identify structural diverse xanthones and search for novel antitumor natural products from this family plants. Methods The structures
Cuicui Jia +6 more
doaj +1 more source
Zika Virus Inhibitors Based on a 1,3-Disubstituted 1H-Pyrazolo[3,4-d]pyrimidine-amine Scaffold
Molecules, 2022 To search for Zika virus (ZIKV) antivirals, we have further explored previously reported 7H-pyrrolo[2,3-d]pyrimidines by examining an alternative substitution pattern of their central scaffold, leading to compound 5 with low micromolar antiviral activity.
Eunkyung Jung +3 more
doaj +1 more source
A structural keystone for drug design [PDF]
Journal of Integrative Bioinformatics, 2006 Abstract 3D-structures of proteins and potential ligands are the cornerstones of rational drug design. The first brick to build upon is selecting a protein target and finding out whether biologically active compounds are known. Both tasks require more information than the structures themselves provide.
Mathias Dunkel +6 more
openaire +3 more sources
Depth of anesthesia control using internal model control techniques [PDF]
, 2010 The major difficulty in the design of closed-loop control during anaesthesia is the inherent patient variability due to differences in demographic and drug tolerance.
Anna, Shahab, Wen, Peng
core +2 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Scientific Reports, 2017 An efficient and environmentally friendly method was designed for the oxidation of sulfides to sulfoxides with a recyclable, carbon-skeleton-based heterogeneous catalyst developed by titanium sulfate [Ti(SO4)2] mineralization on the surface of graphene ...
Qinghe Wang +9 more
doaj +1 more source
Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease
Antioxidants, 2023 3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-mercaptopyruvate
Swetha Pavani Rao +3 more
doaj +1 more source
Intelligent wayfinding vehicle design based on visual recognition [PDF]
arXiv, 2022 Intelligent drug delivery trolley is an advanced intelligent drug delivery equipment. Compared with traditional manual drug delivery, it has higher drug delivery efficiency and lower error rate. In this project, an intelligent drug delivery car is designed and manufactured, which can recognize the road route and the room number of the target ward ...
arxiv
Teaching of Critical Analysis of Drug Advertisements to Medical Students [PDF]
, 2011 Background: Medical practitioners utilize drug promotional materials from pharmaceutical companies as a major source of information especially in developing countries.
Adiga, S, Bairy, KL, Chogtu, B, Nayak, V
core +1 more source