Neurobiology of Disease, 2021 Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques causing synaptic dysfunction and neuronal death. Neurons rely on astrocyte-derived glutamine for replenishment of the amino acid neurotransmitter pools.
Jens V. Andersen +7 more
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Searching for novel carbonic anhydrase inhibitors: from virtual screening to the lab bench [PDF]
, 2013 Carbonic Anhydrases (CAs) are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate both in prokaryotes and eukaryotes.
Cadoni, Roberta +8 more
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Factors associated with the performance and cost-effectiveness of using lymphatic filariasis transmission assessment surveys for monitoring soil-transmitted helminths: a case study in Kenya. [PDF]
, 2015 Transmission assessment surveys (TAS) for lymphatic filariasis have been proposed as a platform to assess the impact of mass drug administration (MDA) on soil-transmitted helminths (STHs).
Assefa +34 more
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Scientific Reports, 2017 An efficient and environmentally friendly method was designed for the oxidation of sulfides to sulfoxides with a recyclable, carbon-skeleton-based heterogeneous catalyst developed by titanium sulfate [Ti(SO4)2] mineralization on the surface of graphene ...
Qinghe Wang +9 more
doaj +1 more source
Removal of Tetracycline in Sewage and Dairy Products with High-Stable MOF
Molecules, 2020 Serious environmental and human health problems caused by the abuse of antibiotics have attracted worldwide concern. Recently, metal−organic frameworks (MOFs) with high porosity have drawn wide attention for their effects in the adsorption and ...
Kan Li +4 more
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Geriatric pharmacotherapy : optimisation through integrated approach in the hospital setting [PDF]
, 2016 Since older patients are more vulnerable to adverse drug-related events, there is a need to ensure appropriate prescribing in these patients in order to prevent misuse, overuse and underuse of drugs.
A Corsonello +63 more
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A pair of new enantiomers of xanthones from the stems and leaves of Cratoxylum cochinchinense
Chinese Medicine, 2019 Background The simple and caged xanthones from Clusiaceae showed significant antineoplastic activity. This study aims to identify structural diverse xanthones and search for novel antitumor natural products from this family plants. Methods The structures
Cuicui Jia +6 more
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Molecular Dynamics Studies on HIV-1 Protease: Drug Resistance and Folding Pathways [PDF]
, 2001 Drug resistance to HIV-1 Protease involves accumulation of multiple mutations in the protein. Here we investigate the role of these mutations by using molecular dynamics simulations which exploit the influence of the native-state topology in the folding ...
Carloni, Paolo +3 more
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Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method
Scientific Reports, 2017 Virtual screening offers an efficient alternative to high-throughput screening in the identification of pharmacological tools and lead compounds. Virtual screening is typically based on the matching of target structures or ligand pharmacophores to ...
Ida Osborn Frandsen +7 more
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Benchmarking network propagation methods for disease gene identification [PDF]
, 2019 In-silico identification of potential target genes for disease is an essential aspect of drug target discovery. Recent studies suggest that successful targets can be found through by leveraging genetic, genomic and protein interaction information.
Barrett, Steven J. +5 more
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