Results 91 to 100 of about 21,694,813 (356)

Beyond ‘peer pressure’: rethinking drug use and ‘youth culture’ [PDF]

, 2006
The study of drug use by young people in the West has been transformed over the last decade by the development of sociological approaches to drug use which take serious account of the cultural context in which young people encounter drugs.
Applebaum, Bennett, Blackman, Bykov, Dean, Duff, Fitzgerald, Flaker, Gossop, Grassly, Green, Hilary Pilkington, Johnston, Kelly, Koshkina, Kramer, MacDonald, Malikova, McKee, Measham, Miles, O’Malley, Paoli, Parker, Parker, Pearson, Pilkington, Pilkington, Pilkington, Pilkington, Platt, Power, Ranard, Rhodes, Rhodes, Rhodes, Rhodes, Shildrick, Shiner, Stozharova, Taylor, Zhuravleva   +41 more
core   +1 more source

A Comprehensive Review on Current Advances in Peptide Drug Development and Design

International Journal of Molecular Sciences, 2019
Protein–protein interactions (PPIs) execute many fundamental cellular functions and have served as prime drug targets over the last two decades. Interfering intracellular PPIs with small molecules has been extremely difficult for larger or flat binding ...
A. Lee, J. Harris, K. Khanna, Ji-Hong Hong   +3 more
semanticscholar   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Thyrogrit, supplemented with a sub-optimal dose of levothyroxine, restores thyroid function in rat model of propylthiouracil-induced hypothyroidism

Clinical Phytoscience
Background Hypothyroidism is a common endocrine ailment, whose current standard of care is hormonal replacement therapy with levothyroxine (LT4). There is a medical need for alternative and safer therapies as LT4 is associated with special treatment ...
Acharya Balkrishna, Ritu Paliwal, Madhulina Maity, Yash Varshney, Sandeep Sinha, Anurag Varshney   +5 more
doaj   +1 more source

Indicators of prescribing quality in drug utilisation research: report of a European meeting (DURQUIM, 13-15 May 2004) [PDF]

, 2005
An invitational expert meeting on indicators of prescribing quality was held on 13-15 May 2004, bringing together-from 19 European countries, the US, Canada, and Australia-40 researchers specialized in the development and application of indicators.
Haaijer-Ruskamp, F.M., Hoven, J.L., Vander Stichele, R.H.   +2 more
core   +3 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Therapeutic potential of AAV2-shmTOR gene therapy in reducing retinal inflammation and preserving endothelial Integrity in age-related macular degeneration

Scientific Reports
Age-related macular degeneration (AMD) is a prevalent retinal disorder that leads to central vision loss, mainly due to chronic inflammation. Tumor necrosis factor-alpha (TNF-α) is a critical mediator of inflammatory responses within the retinal ...
Jin Kim, Seo Yun Moon, Ho Geun Kang, Hee Jong Kim, Jun Sub Choi, Steven Hyun Seung Lee, Keerang Park, So-Yoon Won   +7 more
doaj   +1 more source

Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response

Frontiers in Pharmacology, 2020
The widely used cancer treatment, chemotherapy, causes severe long-term neuropathic pain in 30–40% cases, the condition clinically known as chemotherapy-induced peripheral neuropathy (CIPN).
Acharya Balkrishna, Acharya Balkrishna, Sachin S. Sakat, Shadrak Karumuri, Hoshiyar Singh, Meenu Tomer, Ajay Kumar, Niti Sharma, Pradeep Nain, Swati Haldar, Anurag Varshney, Anurag Varshney   +11 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Study of Acute Toxicity of a New Veterinary Drug for Inttrammary Introduction [PDF]

, 2018
Preclinical studies of veterinary medicinal products are important and compulsory studies in the development of new dosage forms. The aim of preclinical research is to determine the toxic effect and therapeutic efficacy of the test substance-the future ...
Polova, Z. (Zhanna)
core