Results 11 to 20 of about 2,218,427 (310)

Immuno-oncology combinations: raising the tail of the survival curve

Cancer Biology & Medicine, 2016
There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S.
Samuel J. Harris, Jessica Brown, Juanita Lopez, Timothy A. Yap   +3 more
doaj   +1 more source

Super-critical fluid extract of Bryonopsis laciniosa (Shivlingi) seeds restores fertility in zebrafish models through revival of cytological and anatomical features

Journal of Ovarian Research, 2022
Background The Ayurvedic system of medicine mentions the use of seeds of Bryonopsis laciniosa (L.) Naud. (also known as Shivlingi due to their unique structure resembling a ‘Shivling’) for treating sexual dysfunction, impaired fertility, and as a general
Acharya Balkrishna, Pradeep Nain, Monali Joshi, Brijesh Kumar, Anurag Varshney   +4 more
doaj   +1 more source

Drug Development: Stages of Drug Development [PDF]

Journal of Pharmacovigilance, 2015
New drug development program for the different compound is initiated because there is a disease or clinical condition without suitable pharmacotherapeutic products available. New drug development can proceed along varied pathways for different compounds.
openaire   +1 more source

Drug Development☆

, 2007
openAccessArticle: False ; cover date: 2015-01-01 ; pii: B978-0-12-801238-3.04980-1 ; Harvest Date: 2016-01-06 13:08:13 ; issueName: ; Page Range: - ; href scidir: http://www.sciencedirect.com/science/article/pii/B9780128012383049801 ; pubType:
L., Wecker, Wecker, L., Krzanowski, J.
openaire   +4 more sources

Correction to: Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease

BMC Cancer, 2021
An amendment to this paper has been published and can be accessed via the original article.
Dearbhaile Catherine Collins, Raghav Sundar, Anastasia Constantinidou, David Dolling, Timothy Anthony Yap, Sanjay Popat, Mary E. O’Brien, Udai Banerji, Johann Sebastian de Bono, Juanita Suzanne Lopez, Nina Tunariu, Anna Minchom   +11 more
doaj   +1 more source

Dopaminergic cell protection and alleviation of neuropsychiatric disease symptoms by VMAT2 expression through the class I HDAC inhibitor TC‐H 106

Pharmacology Research & Perspectives, 2023
The importance of vesicular monoamine transporter 2 (VMAT2) in dopamine regulation, which is considered crucial for neuropsychiatric disorders, is currently being studied.
Heejin Lee, Hye‐Ji Kim, Dong‐Kyu Choi, Eu n.‐A. Ko, Jae‐Hyeog Choi, Yohan Seo, Sion Lee, Soong‐Hyun Kim, Sejin Jung, Minwoo Kim, Dongwan Kang, Chun‐Young Im, Gi‐Hun Bae, Sung‐Cherl Jung, Oh‐Bin Kwon   +14 more
doaj   +1 more source

Drug development, radiolabeled drugs and PET

Annals of Medicine, 1999
Positron emission tomography (PET) provides noninvasive in vivo quantitative pharmacokinetic and pharmacodynamic information on novel and established drugs. Because only very low amounts of the (potential) drug have to be administered, far below toxicity levels, human studies can be carried out even before the drug is entered in phase I studies.
Vaalburg, Willem, Hendrikse, N. Harry, De Vries, Erik F.J.   +2 more
openaire   +4 more sources

Randomized clinical trial to assess the protective efficacy of a Plasmodium vivax CS synthetic vaccine

Nature Communications, 2022
In this phase 2 clinical trial, the authors assess protective efficacy of a Plasmodium vivax circumsporozoite vaccine in naïve and semi-immune individuals from controlled human malaria infection as well as antibody and IFN-γ response to vaccination.
Myriam Arévalo-Herrera, Xiomara Gaitán, Michelle Larmat-Delgado, María Alejandra Caicedo, Sonia M. Herrera, Juliana Henao-Giraldo, Angélica Castellanos, Jean-Christophe Devaud, André Pannatier, José Oñate, Giampietro Corradin, Sócrates Herrera   +11 more
doaj   +1 more source

The role of microglial P2X7: modulation of cell death and cytokine release

Journal of Neuroinflammation, 2017
Background ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflammation.
Yingbo He, Natalie Taylor, Lawrence Fourgeaud, Anindya Bhattacharya   +3 more
doaj   +1 more source

Stressful Events Reported by Childhood Cancer Survivors and Community Controls From the St. Jude Lifetime (SJLIFE) Cohort: A Mixed Method Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Characterizing stressful events reported by childhood cancer survivors experienced throughout the lifespan may help improve trauma‐informed care relevant to the survivor experience. Methods Participants included 2552 survivors (54% female; 34 years of age) and 469 community controls (62% female; 33 years of age) from the St.
Megan E. Ware, Colter K. Clayton, Fang Wang, Sedigheh Mirzaei, Kyla Shelton, Tara M. Brinkman, Victoria Willard, Katianne M. Howard Sharp, Kevin Krull, Lindsay F. Schwartz, Melissa M. Hudson, Gregory T. Armstrong, Kirsten K. Ness, Rachel T. Webster   +13 more
wiley   +1 more source