Results 21 to 30 of about 4,166,507 (358)

Super-critical fluid extract of Bryonopsis laciniosa (Shivlingi) seeds restores fertility in zebrafish models through revival of cytological and anatomical features

Journal of Ovarian Research, 2022
Background The Ayurvedic system of medicine mentions the use of seeds of Bryonopsis laciniosa (L.) Naud. (also known as Shivlingi due to their unique structure resembling a ‘Shivling’) for treating sexual dysfunction, impaired fertility, and as a general
Acharya Balkrishna, Pradeep Nain, Monali Joshi, Brijesh Kumar, Anurag Varshney   +4 more
doaj   +1 more source

Melatonergic drugs in development

Clinical Pharmacology: Advances and Applications, 2014
Melatonin (N-acetyl-5-methoxytryptamine) is widely known as "the darkness hormone". It is a major chronobiological regulator involved in circadian phasing and sleep-wake cycle in humans. Numerous other functions, including cyto/neuroprotection, immune modulation, and energy metabolism have been ascribed to melatonin.
CAROCCI, ALESSIA, CATALANO, ALESSIA, SINICROPI MS   +2 more
openaire   +7 more sources

Correction to: Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease

BMC Cancer, 2021
An amendment to this paper has been published and can be accessed via the original article.
Dearbhaile Catherine Collins, Raghav Sundar, Anastasia Constantinidou, David Dolling, Timothy Anthony Yap, Sanjay Popat, Mary E. O’Brien, Udai Banerji, Johann Sebastian de Bono, Juanita Suzanne Lopez, Nina Tunariu, Anna Minchom   +11 more
doaj   +1 more source

Dopaminergic cell protection and alleviation of neuropsychiatric disease symptoms by VMAT2 expression through the class I HDAC inhibitor TC‐H 106

Pharmacology Research & Perspectives, 2023
The importance of vesicular monoamine transporter 2 (VMAT2) in dopamine regulation, which is considered crucial for neuropsychiatric disorders, is currently being studied.
Heejin Lee, Hye‐Ji Kim, Dong‐Kyu Choi, Eu n.‐A. Ko, Jae‐Hyeog Choi, Yohan Seo, Sion Lee, Soong‐Hyun Kim, Sejin Jung, Minwoo Kim, Dongwan Kang, Chun‐Young Im, Gi‐Hun Bae, Sung‐Cherl Jung, Oh‐Bin Kwon   +14 more
doaj   +1 more source

Drug development, radiolabeled drugs and PET

Annals of Medicine, 1999
Positron emission tomography (PET) provides noninvasive in vivo quantitative pharmacokinetic and pharmacodynamic information on novel and established drugs. Because only very low amounts of the (potential) drug have to be administered, far below toxicity levels, human studies can be carried out even before the drug is entered in phase I studies.
Vaalburg, Willem, Hendrikse, N. Harry, De Vries, Erik F.J.   +2 more
openaire   +5 more sources

Pharmacogenomics and Drug Development [PDF]

Pharmacogenomics, 2005
It is generally anticipated that pharmacogenomic information will have a large impact on drug development and will facilitate individualized drug treatment. However, there has been relatively little quantitative modeling to assess how pharmacogenomic information could be best utilized in clinical practice.
Steven L. Shafer, Steven L. Shafer, Gary Peltz, Gary Peltz, Yingying Guo, Paul Weller, Paul Weller, Jonathan Usuka, Jonathan Usuka   +8 more
openaire   +3 more sources

Prediction of the permeability of neutral drugs inferred from their solvation properties [PDF]

, 2015
Determination of drug absorption is an important component of the drug discovery and development process in that it plays a key role in the decision to promote drug candidates to clinical trials.
Milanetti, Edoardo, Raimondo, Domenico, Tramontano, Anna   +2 more
core   +1 more source

Randomized clinical trial to assess the protective efficacy of a Plasmodium vivax CS synthetic vaccine

Nature Communications, 2022
In this phase 2 clinical trial, the authors assess protective efficacy of a Plasmodium vivax circumsporozoite vaccine in naïve and semi-immune individuals from controlled human malaria infection as well as antibody and IFN-γ response to vaccination.
Myriam Arévalo-Herrera, Xiomara Gaitán, Michelle Larmat-Delgado, María Alejandra Caicedo, Sonia M. Herrera, Juliana Henao-Giraldo, Angélica Castellanos, Jean-Christophe Devaud, André Pannatier, José Oñate, Giampietro Corradin, Sócrates Herrera   +11 more
doaj   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Germi-X herbal-based spray disinfects smartphone surfaces: implication on fomite-mediated infection spread

AMB Express, 2022
Inanimate objects/surfaces become fomites upon contacting infectious agents such as disease-causing bacteria, fungi and viruses. Smartphones are one of the most prominent among these fomites.
Acharya Balkrishna, Kanchan Singh, Swati Haldar, Anurag Varshney   +3 more
doaj   +1 more source