Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD). [PDF]
, 2014 Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor sensitivity in forced expiratory volume in one second (FEV1), numerous causes are known to contribute to ...
Danhof, M +6 more
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The role of microglial P2X7: modulation of cell death and cytokine release
Journal of Neuroinflammation, 2017 Background ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflammation.
Yingbo He +3 more
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Scientific Reports, 2022 Withania somnifera (L.) Dunal (Ashwagandha) is widely used in Ayurveda, Unani and Siddha systems of medicines due to its therapeutic application in numerous ailments.
Acharya Balkrishna +3 more
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The use of drug calendars for the diagnosis of cutaneous drug eruptions in the age of electronic medical records [PDF]
, 2020 A morbilliform drug eruption is the most common condition leading to a dermatology consultation for a patient in the hospital. Timing is an important diagnostic tool since the onset of a skin rash usually takes place within days-to-weeks of the start of ...
Cohen, Philip R, Grossman, Marc E
core
Functional analysis and transcriptional output of the Göttingen minipig genome [PDF]
, 2015 In the past decade the Göttingen minipig has gained increasing recognition as animal model in pharmaceutical and safety research because it recapitulates many aspects of human physiology and metabolism.
Badi, Laura +21 more
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Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology. [PDF]
, 2019 Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped onto a single tumor's clinical phenotype thereby revealing commonalities shared by cancers with divergent phenotypes.
Goetzl, Edward J +4 more
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, 2007 openAccessArticle: False ; cover date: 2015-01-01 ; pii: B978-0-12-801238-3.04980-1 ; Harvest Date: 2016-01-06 13:08:13 ; issueName: ; Page Range: - ; href scidir: http://www.sciencedirect.com/science/article/pii/B9780128012383049801 ; pubType:
L., Wecker, Wecker, L., Krzanowski, J.
openaire +3 more sources
Molecular similarity for machine learning in drug development : poster presentation [PDF]
, 2008 Poster presentation In pharmaceutical research and drug development, machine learning methods play an important role in virtual screening and ADME/Tox prediction.
Proschak, Ewgenij +2 more
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Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease
BMC Cancer, 2020 Background Malignant pleural mesothelioma (MPM) is traditionally characterized by local destructive spread of the pleura and surrounding tissues. Patient outcomes in MPM with distant metastatic dissemination are lacking.
Dearbhaile Catherine Collins +11 more
doaj +1 more source
Drug metabolism in drug discovery and development
Acta Pharmaceutica Sinica B, 2018 Drug metabolism as a discipline plays an important role in drug discovery and development and the effects of drug metabolism on pharmacokinetics (PK), pharmacodynamics (PD), and safety should be carefully considered. This communication provides an overview of common strategies in the area of drug metabolism for improving PK/PD and safety profiles of ...
Wei Tang, Zhoupeng Zhang
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