Results 31 to 40 of about 21,694,813 (356)
Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology. [PDF]
, 2019 Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped onto a single tumor's clinical phenotype thereby revealing commonalities shared by cancers with divergent phenotypes.
Goetzl, Edward J +4 more
core +2 more sources
The Alzheimer’s disease drug development landscape
Alzheimer's Research & Therapy, 2021 Alzheimer’s disease (AD) is a devastating neurodegenerative disease leading to dementia. The field has made significant progress over the last 15 years. AD diagnosis has shifted from syndromal, based on signs and symptoms, to a biomarker construct based ...
P. van Bokhoven +7 more
semanticscholar +1 more source
Alzheimer's disease drug development pipeline: 2020
Alzheimer's & Dementia, 2020 Alzheimer's disease (AD) is a growing public health concern affecting millions of patients worldwide and costing billions of dollars annually. We review the pipeline of drugs and biologics in clinical trials for the treatment of AD.
J. Cummings +4 more
semanticscholar +2 more sources
Repurposed agents in the Alzheimer’s disease drug development pipeline
Alzheimer's Research & Therapy, 2020 Treatments are needed to address the growing prevalence of Alzheimer’s disease (AD). Clinical trials have failed to produce any AD drugs for Food and Drug Administration (FDA) approval since 2003, and the pharmaceutical development process is both time ...
J. Bauzon, Garam Lee, J. Cummings
semanticscholar +1 more source
Molecular similarity for machine learning in drug development : poster presentation [PDF]
, 2008 Poster presentation In pharmaceutical research and drug development, machine learning methods play an important role in virtual screening and ADME/Tox prediction.
Proschak, Ewgenij +2 more
core +1 more source
Nature Communications, 2022 In this phase 2 clinical trial, the authors assess protective efficacy of a Plasmodium vivax circumsporozoite vaccine in naïve and semi-immune individuals from controlled human malaria infection as well as antibody and IFN-γ response to vaccination.
Myriam Arévalo-Herrera +11 more
doaj +1 more source
Costs of Drug Development and Research and Development Intensity in the US, 2000-2018
JAMA Network OpenKey Points Question What is the mean cost of drug development for the US market, and how has research and development (R&D) intensity changed over time? Findings This economic evaluation study used data from public and proprietary sources to estimate the
A. Sertkaya +3 more
semanticscholar +1 more source
Signal Transduction and Targeted TherapyAlzheimer’s disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. Its etiology is intricate and diverse, stemming from a combination of factors such as aging, genetics, and environment.
Jifa Zhang +5 more
semanticscholar +1 more source
The role of microglial P2X7: modulation of cell death and cytokine release
Journal of Neuroinflammation, 2017 Background ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflammation.
Yingbo He +3 more
doaj +1 more source
AMB Express, 2022 Inanimate objects/surfaces become fomites upon contacting infectious agents such as disease-causing bacteria, fungi and viruses. Smartphones are one of the most prominent among these fomites.
Acharya Balkrishna +3 more
doaj +1 more source