Results 151 to 160 of about 568,926 (318)
Molecular Oncology, EarlyView.Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan +4 more
wiley +1 more source
Lenacapavir's success: Revitalizing antiviral drug discovery. [PDF]
VirulenceMiranda D, Sanchez DJ.
europepmc +1 more source
STAT proteins: novel molecular targets for cancer drug discovery
, 2000 James Turkson, Richard Jove
openalex +1 more source
Molecular Oncology, EarlyView.Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley +1 more source
A new paradigm for drug discovery in the treatment of complex diseases: drug discovery and optimization. [PDF]
Chin MedYuan Y +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
AI-Driven Polypharmacology in Small-Molecule Drug Discovery. [PDF]
Int J Mol SciAbdelsayed M.
europepmc +1 more source