Results 11 to 20 of about 5,975,518 (353)
Generative artificial intelligence empowers digital twins in drug discovery and clinical trials
Expert Opinion on Drug Discovery, 2023 Introduction The concept of Digital Twins (DTs) translated to drug development and clinical trials describes virtual representations of systems of various complexities, ranging from individual cells to entire humans, and enables in silico simulations and
Maria Bordukova +4 more
semanticscholar +1 more source
Accelerating antiviral drug discovery: lessons from COVID-19
Nature reviews. Drug discovery, 2023 During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and collaborative drug discovery efforts took place in academia and industry, culminating in several therapeutics being discovered, approved and deployed in a 2-year time frame ...
Annette von Delft +7 more
semanticscholar +1 more source
Drug Repurposing: An Effective Tool in Modern Drug Discovery
Russian journal of bioorganic chemistry, 2023 Drug repurposing is using an existing drug for a new treatment that was not indicated before. It has received immense attention during the COVID-19 pandemic emergency.
V. Kulkarni +4 more
semanticscholar +1 more source
Antimalarial drug discovery: progress and approaches
Nature reviews. Drug discovery, 2023 Recent antimalarial drug discovery has been a race to produce new medicines that overcome emerging drug resistance, whilst considering safety and improving dosing convenience.
Jair L. Siqueira-Neto +5 more
semanticscholar +1 more source
Scientific Reports, 2021 Accumulation of tau protein is a key pathology of age-related neurodegenerative diseases such as Alzheimer's disease and progressive supranuclear palsy. Those diseases are collectively termed tauopathies.
Tomohiro Onishi +8 more
doaj +1 more source
Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition
Communications Biology, 2021 Mimasu et al. report a rat full-length structure of kynurenine 3-monooxygenase (KMO) in its membrane-embedded form, complexed with two inhibitors. They find that the dimeric interface of KMO is critical for its activity. This study provides insights into
Shinya Mimasu +10 more
doaj +1 more source
Fragments and hot spots in drug discovery [PDF]
, 2015 R01 GM064700 - NIGMS NIH HHSPublished ...
Kozakov, Dima +2 more
core +2 more sources
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
Journal of Cheminformatics, 2014 BackgroundModern medicine often clashes with traditional medicine such as Chinese herbal medicine because of the little understanding of the underlying mechanisms of action of the herbs. In an effort to promote integration of both sides and to accelerate
Jinlong Ru +13 more
semanticscholar +1 more source
Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring. [PDF]
, 2019 The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with innovative new therapeutic modalities, paving the way to breakthrough therapies for previously ...
Chen, Ching +17 more
core +1 more source
m6A modification: recent advances, anticancer targeted drug discovery and beyond
Molecular Cancer, 2022 Abnormal N6-methyladenosine (m6A) modification is closely associated with the occurrence, development, progression and prognosis of cancer, and aberrant m6A regulators have been identified as novel anticancer drug targets.
Lijuan Deng +10 more
semanticscholar +1 more source