Results 11 to 20 of about 1,303,108 (353)
Sustainability in drug discovery
Medicine in Drug Discovery, 2021 Due to the expanding and ageing world population, the importance and use of medicines is expected to increase. However, this will lead to a greater impact on the ecosystem and our health in the long term.The concept of sustainability is rather slowly gaining traction and is currently still fragmented in the pharmaceutical field.
Wynendaele, Evelien +11 more
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Aging and drug discovery [PDF]
Aging, 2018 ISSN:1945 ...
Michael Ristow +25 more
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Current Opinion in Structural Biology, 2023 The cryo-electron microscopy (cryo-EM) method microcrystal electron diffraction (MicroED) was initially described in 2013 and has recently gained attention as an emerging technique for research in drug discovery. As compared to other methods in structural biology, MicroED provides many advantages deriving from the use of nanocrystalline material for ...
Emma Danelius +3 more
openaire +4 more sources
MedChemComm, 2019 Exploiting glycan recognition in drug discovery.
Ana Ardá +5 more
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Antibiotic drug discovery [PDF]
Microbial Biotechnology, 2016 SummaryDue to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the past few years. This has been the
Yvonne Mast +3 more
openaire +3 more sources
Fragments and hot spots in drug discovery [PDF]
, 2015 R01 GM064700 - NIGMS NIH HHSPublished ...
Kozakov, Dima +2 more
core +2 more sources
Journal of Translational Medicine, 2016 Background Angiopoietin-2 (Ang-2), a ligand of the Tie-2 receptor, plays an important role in maintaining endothelial cells and in destabilizing blood vessels. Collateral artery growth (arteriogenesis) is a key adaptive response to arterial occlusion. It
Xiaoyong Tan +11 more
doaj +1 more source
Disruptive Strategies for Removing Drug Discovery Bottlenecks [PDF]
, 2012 Drug Discovery is shifting focus from the industry to outside partners and in the process creating new bottlenecks, suggesting the need for a more disruptive overhaul.
Antony Williams +4 more
core +2 more sources
Toxins and drug discovery [PDF]
Toxicon, 2014 Components from venoms have stimulated many drug discovery projects, with some notable successes. These are briefly reviewed, from captopril to ziconotide. However, there have been many more disappointments on the road from toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes
openaire +4 more sources
Cheminformatics Models for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase
The Scientific World Journal, 2014 Schistosomiasis is a neglected tropical disease caused by a parasite Schistosoma mansoni and affects over 200 million annually. There is an urgent need to discover novel therapeutic options to control the disease with the recent emergence of drug ...
Sonam Gaba +3 more
doaj +1 more source