Results 11 to 20 of about 1,359,668 (353)

Sustainability in drug discovery

Medicine in Drug Discovery, 2021
Due to the expanding and ageing world population, the importance and use of medicines is expected to increase. However, this will lead to a greater impact on the ecosystem and our health in the long term.The concept of sustainability is rather slowly gaining traction and is currently still fragmented in the pharmaceutical field.
Wynendaele, Evelien, Furman, Christophe, Wielgomas, Bartosz, Larsson, Per, Hak, Eelko, Block, Thomas, Van Calenbergh, Serge, Willand, Nicolas, Markuszewski, Michal, Odell, Luke R., Poelarends, Gerrit J., De Spiegeleer, Bart   +11 more
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Aging and drug discovery [PDF]

Aging, 2018
ISSN:1945 ...
Michael Ristow, Martijn S. Luijsterburg, Judith Campisi, Judith Campisi, Alex Zhavoronkov, Olga Kovalchuk, Vadim N. Gladyshev, Vadim N. Gladyshev, Alexander Aliper, Alejandro Martin-Montalvo, Dudley W. Lamming, Amanuel Teklu, Daniela Bakula, Collin Y. Ewald, Ivan V. Ozerov, Joseph A. Baur, Michael A. Petr, Garik Mkrtchyan, Alexey Moskalev, Alexey Moskalev, Anastasia Georgievskaya, Alexander Pickett, Morten Scheibye-Knudsen, Polina Mamoshina, S. Jay Olshansky, Stuart Maudsley   +25 more
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MicroED in drug discovery

Current Opinion in Structural Biology, 2023
The cryo-electron microscopy (cryo-EM) method microcrystal electron diffraction (MicroED) was initially described in 2013 and has recently gained attention as an emerging technique for research in drug discovery. As compared to other methods in structural biology, MicroED provides many advantages deriving from the use of nanocrystalline material for ...
Emma Danelius, Khushboo Patel, Brenda Gonzalez, Tamir Gonen   +3 more
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Glycans in drug discovery

MedChemComm, 2019
Exploiting glycan recognition in drug discovery.
Ana Ardá, Niels-Christian Reichardt, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero, Ana Gimeno, Pablo Valverde   +5 more
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Antibiotic drug discovery [PDF]

Microbial Biotechnology, 2016
SummaryDue to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the past few years. This has been the
Yvonne Mast, Evi Stegmann, Nadine Ziemert, Wolfgang Wohlleben   +3 more
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Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritis

Advances in Rheumatology, 2022
Objectives To assess the ability of monoclonal antibodies (mAbs) specific for fibronectin extra-domain A (FnEDA) to target diseased tissues of mouse collagen induced arthritis (mCIA) models.
Victor Z. Sun, Terry L. Melim, Soumya Mitra, Jamie E. Erickson, Shaughn H. Bryant, Avery Farnham, Susan Westmoreland, Heather Knight, Liang Zhang, Wendy Ritacco, Kristoff Homan, Lorenzo Benatuil, Annette J. Schwartz Sterman, Andrew D. Goodearl   +13 more
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Toxins and drug discovery [PDF]

Toxicon, 2014
Components from venoms have stimulated many drug discovery projects, with some notable successes. These are briefly reviewed, from captopril to ziconotide. However, there have been many more disappointments on the road from toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes
openaire   +4 more sources

Cheminformatics Models for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase

The Scientific World Journal, 2014
Schistosomiasis is a neglected tropical disease caused by a parasite Schistosoma mansoni and affects over 200 million annually. There is an urgent need to discover novel therapeutic options to control the disease with the recent emergence of drug ...
Sonam Gaba, Salma Jamal, Open Source Drug Discovery Consortium, Vinod Scaria   +3 more
doaj   +1 more source

Conversion of Aquaculture Waste into Biomedical Wealth: Chitin and Chitosan Journey

Advances in Materials Science and Engineering, 2022
Biowaste originating from aquaculture sector represents a potential feedstock to produce value-added substances and materials like chitin and chitosan. They are the long chain polymers of N-acetylglucosamine polymers with huge industrial and biomedical ...
Jerrine Joseph, Kaari Manigundan, Mary Shamya Arokia Rajan, Manikkam Radhakrishnan, Venugopal Gopikrishnan, Subramanian Kumaran, Rajasekar Thirunavukkarasu, Wilson Aruni, Velmurugan Shanmugam   +8 more
doaj   +1 more source

Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB. [PDF]

, 2016
Repurposing has gained momentum globally and become an alternative avenue for drug discovery because of its better success rate, and reduced cost, time and issues related to safety than the conventional drug discovery process.
Brindha, Sridharan, Gnanadoss, John Joel, Sundaramurthi, Jagadish Chandrabose, Velmurugan, Devadasan, Vincent, Savariar   +4 more
core   +1 more source