Results 161 to 170 of about 516,097 (212)

Increasing the Selectivity of Drug Discrimination Procedures

Pharmacology Biochemistry and Behavior, 1998
In an attempt to increase the selectivity of drug discrimination, rats were trained to discriminate LSD (0.08 mg/kg) from a group of "other" compounds consisting of cocaine (10 mg/kg), pentobarbital (5 mg/kg), and saline. Acquisition of this LSD-other discrimination was rapid (31 days) in chambers equipped with retractable levers and did not differ ...
Alici, TEVFİK, Pechersky, K, Rolandi, WG, West, WB, Appel, JB   +4 more
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Hallucinogens in Drug Discrimination

2017
Hallucinogens comprise a diverse collection of chemicals with multifarious receptor actions in the central nervous system. Preclinical drug screening methods have proven invaluable in the evaluation and characterization of hallucinogen psychopharmacology.
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Discriminative stimulus functions of CNS sedative drugs assessed by drug versus drug discrimination procedures in gerbils

Psychopharmacology, 1998
This study is concerned with dissecting out differences in the discriminative stimulus attributes between drugs from broader pharmacological categories such as sedative/hypnotics where generalization tests often indicate shared stimulus effects. To this end, the discriminative stimulus effects of three to five doses of either chlordiazepoxide (CDP ...
T U, Järbe, M D, Swedberg
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Drug Discrimination Analysis of Pseudoephedrine in Rats

Pharmacology Biochemistry and Behavior, 1998
Rats were trained to discriminate amphetamine, 1 mg/kg given intraperitoneally, from saline injection in a two-lever operant drug discrimination task. Pseudoephedrine (a sympathomimetic drug with central and peripheral actions) at doses of 10 mg/kg failed to substitute for amphetamine, at 20 mg/kg partial substitution occurred, while at a 40 mg/kg full
W, Tongjaroenbuangam, D, Meksuriyen, P, Govitrapong, N, Kotchabhakdi, B A, Baldwin   +4 more
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Diprenorphine as a stimulus in drug discrimination learning

Pharmacology Biochemistry and Behavior, 1992
Using the conditioned taste aversion baseline of drug discrimination learning, animals were trained to discriminate diprenorphine from distilled water. In subsequent generalization tests, the opiate antagonists naltrexone and naloxone and the mixed opiate agonist/antagonist nalorphine substituted for the diprenorphine stimulus in a dose-dependent ...
S T, Smurthwaite, A L, Riley
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Drug discrimination models in anxiety and depression

Pharmacology & Therapeutics, 1990
Drug discrimination is a technique for investigating the stimulus properties of centrally active drugs. Although many studies have employed animals to investigate the stimulus properties of substances used clinically for the treatment of anxiety and depression, it would be a mistake to consider the internal discriminative stimuli as being related ...
J S, Andrews, D N, Stephens
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Four-choice drug discrimination in pigeons

Behavioural Pharmacology, 2001
(+)Amphetamine was added as a training stimulus for pigeons previously trained to discriminate among pentobarbital, morphine and saline using a three-choice procedure. Pigeons quickly learned the four-choice drug discrimination. Generalization from the training drugs was similar to that established with simpler drug discriminations; pentobarbital ...
M, Li, D E, McMillan
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Receptor Mechanisms of Opioid Drug Discrimination

1988
Receptor theory of opioid action has provided an extremely useful interpretive framework for the discriminative stimulus effects of opioids. By and large, receptor theory has been applied to opioid actions as they are measured in in vitro and reflex systems.
J H, Woods, A J, Bertalmio, A M, Young, W D, Essman, G, Winger   +4 more
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Two-drug discrimination within the taste aversion baseline of drug discrimination learning

2023
Typical drug discrimination learning (DDL) uses an operant design in which subjects are trained to respond differentially based on the presence or absence of a drug. One non-operant procedure has emerged which utilizes a modification of the conditioned taste aversion (CTA) design.
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Drug discrimination using a Pavlovian conditional discrimination paradigm in pigeons

Pharmacology Biochemistry and Behavior, 1994
Three pigeons were studied using a discriminated autoshaping procedure in which the presence or absence of methadone served as a conditional stimulus signalling which of two key light CSs would be followed by grain access. Drug sessions alternated randomly with no-drug sessions.
B K, Parker, D W, Schaal, M, Miller
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