Results 81 to 90 of about 13,561,957 (307)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Optimal designs for dose finding studies [PDF]

Identifying the "right" dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated ...
Dette, Holger, Bretz, Frank
core  

Dose-response relationship between tobacco smoking and the risk of composite TB treatment outcomes.

, 2019
Dose-response relationship between tobacco smoking and the risk of composite TB treatment outcomes.
Nikhil Gupte (189999), Nishi Suryavanshi (375258), Kannan Thiruvengadam (796402), Mandar Paradkar (5579405), Padmapriyadarshini Chandrasekaran (6996584), Senthanro Ovung (848525), Shrutha Sivakumar (7109627), Sanjay Gaikwad (6996593), Jonathan E. Golub (296079), Andrea Deluca (4766721), Vidya Mave (541004), Beena Elizabeth Thomas (848523), Shri Vijay Bala Yogendra Shivakumar (796407), Akshay N. Gupte (4433362), Kavitha Dhanasekaran (5579402), Gomathi Narayan Sivaramakrishnan (5579408), Rani S. (7109624), Rewa Kohli (307713), Dileep Kadam (4064449), Neeta Pradhan (5579411), Anju Kagal (375252), C. K. Dolla (7109630), Amita Gupta (21762)   +22 more
core   +1 more source

Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD). [PDF]

, 2014
Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor sensitivity in forced expiratory volume in one second (FEV1), numerous causes are known to contribute to ...
Musuamba, F.T., O. Della Pasqua, H. J. Maas, A. Facius, Della Pasqua, O., Della Pasqua, O, Yang, S., M. Danhof, D. Teutonico, Facius, A, Musuamba, FT, Teutonico, D, Yang, S, Facius, A., Danhof, M., S. Yang, Teutonico, D., Maas, H.J., Maas, HJ, Danhof, M, F. T. Musuamba   +20 more
core   +1 more source

Dose-response relationship of MSCs as living Bio-drugs in HFrEF patients: a systematic review and meta-analysis of RCTs

Stem Cell Research & Therapy
Abstract Background Mesenchymal stem cells (MSCs) have emerged as living biodrugs for myocardial repair and regeneration. Recent randomized controlled trials (RCTs) have reported that MSC-based therapy is safe and effective in heart failure patients; however, its dose-response relationship has yet to be established.
Ziyad T. Ahmed, Maha Saad Zain Al-Abeden, Mohamed Ghaith Al Abdin, Mohamad Ayham Muqresh, Ghazi I. Al Jowf, Lars M. T. Eijssen, Khawaja Husnain Haider   +6 more
openaire   +3 more sources

Supplementary table 3 from Dose–Response Relationship in Phase I Clinical Trials: A European Drug Development Network (EDDN) Collaboration Study

, 2023
<p>Supplementary table 3. Multivariate model for Overall Survival (Cytotoxic Agents)</p>
Stan B. Kaye, Jaap Verweij, Josep Tabernero, Jean Charles Soria, Richard H. Wilson, Ruth Plummer, Jeffrey Evans, Emile Voest, Nicolas Penel, Jan H.M. Schellens, Silvia Marsoni, Patrick Schöffski, Andre T. Brunetto, Elisa Gallerani, Gianluca Del Conte, Rafael Morales-Barrera, Philippe A. Cassier, Carlos Gomez-Roca, David Olmos, Victor Moreno García   +19 more
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Geometric construction of optimal designs for dose-responsemodels with two parameters [PDF]

In dose-response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We derive optimal designs for estimating the underlying dose-response curve for a restricted or unrestricted dose range with respect to a ...
Zhu, Wei, Dette, Holger, Biedermann, Stefanie   +2 more
core  

Dose-response relationship between tooth loss and risk of cardiovascular disease.

, 2018
Dose-response relationship between tooth loss and risk of cardiovascular disease.
Mi Zhang (42795), Xiao Dong (244652), Quan Wang (31224), Haijun Xu (215417), Jiajuan Chen (5029475), Yunjie Wei (5029478), Zhen Gao (609801), Fei Cheng (315348), Fen Qin (4067335)   +8 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source