Results 101 to 110 of about 13,561,957 (307)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Code for Bayesian inference of dose-response curve parameters

, 2016
<p>This is an archived version of the initial release of dose-response-fitting to co-incide with a Wellcome Open Research article.</p> <p>The latest version can be found at: <a href="https://github.com/mirams/dose-response-fitting ...
Bardenet, Remi, Mirams, Gary, Gavaghan, David (8181900), Mirams, Gary (8181891), Gavaghan, David, Johnstone, Ross, Bardenet, Remi (8181897), Johnstone, Ross (8181894)   +7 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Symptom improvement was not significantly associated with weight loss, dose, or treatment duration in women with lipoedema treated with tirzepatide: a retrospective cohort study of prospectively collected outcomes

Metabolism Open
Background: Weight loss may not reliably improve symptoms or adipose tissue abnormalities in lipoedema. Whether symptom improvement during incretin-based pharmacotherapy is associated with the magnitude of weight loss is unknown.
Diogo Pinto da Costa Viana, Adriana Luckow Invitti, Eduardo Schor   +2 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Ozone as U-shaped dose responses molecules (Hormetins)

, 2010
Redox environment involves a broad network of pro-oxidant and antioxidant components. Health benefit or damage can be induced as a consequence of an adaptive cellular stress response.
G. Martínez-Sánchez, A. Giuliani, G. Pérez Davison, L. Re, G. Pérez-Davison, G. Martinez Sanchez   +5 more
core   +1 more source

Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia

Emergency, 2016
Introduction: Midazolam has turned into a common drug for pediatric procedural sedation and analgesia. However, there is not much data regarding its proper dose and potential side effects in the Iranian children population.
Hassan Barzegari, Arash Forouzan, Kambiz Masoumi, Hassan Motamed, Behzad Zohrevandi, Shima Zeynadini Meymand   +5 more
doaj  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Dose Response Relationship for benzophenones.

, 2013
Dose Response Relationship for benzophenones.
Laurence Coiffard (292809), Eva Paparis (292808), Catherine Chauvet (292807), Céline Couteau (292806)   +3 more
core   +1 more source

Response to antiretroviral therapy after a single, peripartum dose of nevirapine. [PDF]

, 2007
BACKGROUND: A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants.
van Widenfelt, Erik, Smeaton, Laura M, Chand, Fatima, Lagakos, Stephen, Shapiro, Roger L, Stevens, Lisa, Novitsky, Vladimir, Wester, Carolyn, Arimi, Peter, Ndase, Patrick, Makhema, Joseph, Asmelash, Aida, Mazhani, Loeto, Lockman, Shahin, Thior, Ibou, Moffat, Claire, Essex, Max   +16 more
core   +1 more source