Results 51 to 60 of about 1,227,223 (348)
Challenges of applying multicellular tumor spheroids in preclinical phase
Cancer Cell International, 2021 The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is becoming an essential tool in cancer research as it expresses an intermediate complexity between 2D monolayer models and in vivo solid tumors.
S. Han, Sangwoo Kwon, K. Kim
semanticscholar +1 more source
Neuroprotective efficacy of P7C3 compounds in primate hippocampus. [PDF]
, 2018 There is a critical need for translating basic science discoveries into new therapeutics for patients suffering from difficult to treat neuropsychiatric and neurodegenerative conditions.
Bauman, Melissa D +8 more
core +2 more sources
Application of Small Epigenetic Modulators in Pediatric Medulloblastoma [PDF]
, 2018 Medulloblastoma is one of the most frequent among pediatric brain tumors, and it has been classified in various subgroups. Some of them already benefit from quite good therapeutic options, whereas others urgently need novel therapeutic approaches ...
Annalisa Romanelli +8 more
core +2 more sources
A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses [PDF]
, 2016 Background. Glioblastoma (GBM) is the most common primary brain tumor, with dismal prognosis. The failure of drug–radiation combinations with promising preclinical data to translate into effective clinical treatments may relate to the use of simplified
Chalmers, Anthony +4 more
core +2 more sources
Ozone therapy improves early stages of osseointegration in ovariectomized rats [PDF]
Journal of Applied Oral ScienceObjective the aim of this study was to analyze the influence of ozone therapy (OZN) on peri-implant bone repair in critical bones by installing osseointegrated implants in the tibia of ovariectomized rats.
William Phillip Pereira da SILVA +8 more
doaj +1 more source
The benefits, limitations and opportunities of preclinical models for neonatal drug development
Disease Models & Mechanisms, 2022 Increased research to improve preclinical models to inform the development of therapeutics for neonatal diseases is an area of great need. This article reviews five common neonatal diseases – bronchopulmonary dysplasia, retinopathy of prematurity ...
Sarah Campion +18 more
doaj +1 more source
A Deep Bayesian Bandits Approach for Anticancer Therapy: Exploration via Functional Prior [PDF]
arXiv, 2022 Learning personalized cancer treatment with machine learning holds great promise to improve cancer patients' chance of survival. Despite recent advances in machine learning and precision oncology, this approach remains challenging as collecting data in preclinical/clinical studies for modeling multiple treatment efficacies is often an expensive, time ...
arxiv
BMC Biology, 2012 There is overwhelming evidence that in vitro three-dimensional tumor cell cultures more accurately reflect the complex in vivo microenvironment than simple two-dimensional cell monolayers, not least with respect to gene expression profiles, signaling ...
M. Vinci +9 more
semanticscholar +1 more source
Current and Future Issues in the Development of Spinal Agents for the Management of Pain. [PDF]
, 2017 Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal ...
Fisher, Casey J +3 more
core +2 more sources
Microorganisms, 2022 In the absence of drugs to treat or prevent COVID-19, drug repurposing can be a valuable strategy. Despite a substantial number of clinical trials, drug repurposing did not deliver on its promise.
Frauke Assmus +30 more
doaj +1 more source