Results 111 to 120 of about 1,243,120 (289)

Analytical and Clinical Evaluation of the PathoNostics AsperGenius Assay for Detection of Invasive Aspergillosis and Resistance to Azole Antifungal Drugs Directly from Plasma Samples [PDF]

, 2017
P. Lewis White, Raquel Posso, Rosemary A. Barnes   +2 more
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Biomimetic lung-on-a-chip to model virus infection and drug evaluation. [PDF]

Eur J Pharm Sci, 2023
Tan J, Guo Q, Tian L, Pei Z, Li D, Wu M, Zhang J, Gao X.   +7 more
europepmc   +1 more source

Evaluation of the Drug–Drug Interaction Potential of the GlyT1 Inhibitor Iclepertin (BI 425809): A Physiologically Based Pharmacokinetic (PBPK) Modeling Approach [PDF]

Elin M. Matsson, Michael Desch, Valerie Nock, Nina Hanke   +3 more
openalex   +1 more source

Evaluation of the Oral Antihyperglycemic Drug Metformin in Normal and Diabetic Cats [PDF]

, 2004
Richard L. Nelson, Dennis Spann, Denise A. Elliott, Angela Brondos, Richard Vulliet   +4 more
openalex   +1 more source

Evaluating the impact of Respiratory Syncytial Virus immunisation strategies on antibiotic use and drug resistant bacterial infections in England

, 2022
Katherine E. Atkins, David Hodgson, Mark Jit, Nicholas G. Davies   +3 more
openalex   +1 more source

Review and expert evaluation of the materials of the European meeting on hypersensitivity to drugs (DHM 2022) [PDF]

, 2022
Olena Sharikadze
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Multi-laboratory comparisons of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practices

Scientific Reports
Acute block of hERG channels is the most common mechanism underlying drug-induced QTC prolongation and potentially fatal Torsade de Pointes arrhythmia. Updates to ICH E14 Q&As now allow for using negative nonclinical data, including hERG, to support QTC ...
Claudia Alvarez Baron, Jun Zhao, Huimei Yu, Ming Ren, Nicolas Thiebaud, Donglin Guo, Giri Vegesna, Cheng-Hui Hsiao, Ryan DePalma, Sabyasachy Mistry, Isra Tariq, Md Shadiqur Rashid Roni, Omnia A. Ismaiel, Murali K. Matta, Vikram Patel, Manni Mashaee, Jose Vicente, Lars Johannesen, Jiansong Sheng, Simon Hebeisen, James Kramer, Andrew Bruening-Wright, Koji Nakano, Hiroshi Matsukawa, Jennifer Beck Pierson, Wendy W. Wu   +25 more
doaj   +1 more source

Retracted: Construction and Drug Evaluation Based on Convolutional Neural Network System Optimized by Grey Correlation Analysis. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source