Results 11 to 20 of about 19,912,299 (390)

Organ-on-a-chip meets artificial intelligence in drug evaluation. [PDF]

Theranostics, 2023
Drug evaluation has always been an important area of research in the pharmaceutical industry. However, animal welfare protection and other shortcomings of traditional drug development models pose obstacles and challenges to drug evaluation.
Deng S, Li C, Cao J, Cui Z, Du J, Fu Z, Yang H, Chen P.   +7 more
europepmc   +2 more sources

Advanced lung organoids and lung-on-a-chip for cancer research and drug evaluation: a review. [PDF]

Front Bioeng Biotechnol, 2023
Lung cancer has become the primary cause of cancer-related deaths because of its high recurrence rate, ability to metastasise easily, and propensity to develop drug resistance.
Zhu L, Zhang J, Guo Q, Kuang J, Li D, Wu M, Mo Y, Zhang T, Gao X, Tan J.   +9 more
europepmc   +2 more sources

Primary Human Pancreatic Cancer Cells Cultivation in Microfluidic Hydrogel Microcapsules for Drug Evaluation. [PDF]

Adv Sci (Weinh), 2023
Chemotherapy is an essential postoperative treatment for pancreatic cancer, while due to the lack of effective drug evaluation platforms, the therapeutic outcomes are hampered by tumor heterogeneity among individuals.
Song T, Zhang H, Luo Z, Shang L, Zhao Y.
europepmc   +2 more sources

Construction of Non-infectious SARS-CoV-2 Replicons and Their Application in Drug Evaluation. [PDF]

Virol Sin, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating pandemic worldwide. Vaccines and antiviral drugs are the most promising candidates for combating this global epidemic, and scientists all over the world have made great
Wang B, Zhang C, Lei X, Ren L, Zhao Z, Wang J, Huang H.   +6 more
europepmc   +2 more sources

Generation of human vascularized and chambered cardiac organoids for cardiac disease modelling and drug evaluation. [PDF]

Cell Prolif
Human induced pluripotent stem cell (hiPSC)‐derived cardiac organoids (COs) have shown great potential in modelling human heart development and cardiovascular diseases, a leading cause of global death.
Yang J, Lei W, Xiao Y, Tan S, Yang J, Lin Y, Yang Z, Zhao D, Zhang C, Shen Z, Hu S.   +10 more
europepmc   +2 more sources

Human Motor System-Based Biohybrid Robot-On-a-Chip for Drug Evaluation of Neurodegenerative Disease. [PDF]

Adv Sci (Weinh), 2023
Biohybrid robots have been developed for biomedical applications and industrial robotics. However, the biohybrid robots have limitations to be applied in neurodegenerative disease research due to the absence of a central nervous system.
Shin M, Ha T, Lim J, An J, Beak G, Choi JH, Melvin AA, Yoon J, Choi JW.   +8 more
europepmc   +2 more sources

Pancreatic cancer cell line in responsive hydrogel microcapsules for drug evaluation

Visual Information Expert Workshop, 2023
Drug therapies are the cornerstone of systemic treatment for pancreatic cancer patients. However, the relative outcome of drug evaluation is often hampered by the complex microenvironment of pancreatic cancer due to the lack of reasonable tumor models ...
Taiyu Song, Hui Zhang, Guangling Liu, Yudong Qiu, Huan Wang   +4 more
semanticscholar   +1 more source

Withdrawing Approval of Makena - A Proposal from the FDA Center for Drug Evaluation and Research.

New England Journal of Medicine, 2020
Withdrawing Approval of Makena The FDA’s Center for Drug Evaluation and Research has recommended withdrawing the approval of Makena for the prevention of recurrent preterm birth after a trial faile...
Christina Y Chang, C. Nguyen, Barbara Wesley, Jia Guo, L. L. Johnson, Hylton V. Joffe   +5 more
semanticscholar   +1 more source

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation [PDF]

BMC Biology, 2012
There is overwhelming evidence that in vitro three-dimensional tumor cell cultures more accurately reflect the complex in vivo microenvironment than simple two-dimensional cell monolayers, not least with respect to gene expression profiles, signaling ...
Maria Vinci, Sharon Gowan, Frances Boxall, Lisa Patterson, Miriam Zimmermann, William Court, C. Lomas, Marta Mendiola, David Hardisson, Suzanne A. Eccles   +9 more
openalex   +2 more sources

Evaluation of Increases in Drug Overdose Mortality Rates in the US by Race and Ethnicity Before and During the COVID-19 Pandemic.

JAMA psychiatry, 2022
Evaluation of Increases in Drug Overdose Mortality Rates in the US by Race and Ethnicity Before and During the COVID-19 Pandemic Drug overdose mortality rates have increased sharply in the US since the COVID-19 pandemic began in 2020.1 Since 2015 ...
J. Friedman, H. Hansen
semanticscholar   +1 more source