Results 11 to 20 of about 18,950,887 (401)
Organ-on-a-chip meets artificial intelligence in drug evaluation. [PDF]
Theranostics, 2023 Drug evaluation has always been an important area of research in the pharmaceutical industry. However, animal welfare protection and other shortcomings of traditional drug development models pose obstacles and challenges to drug evaluation.
Deng S +7 more
europepmc +2 more sources
Primary Human Pancreatic Cancer Cells Cultivation in Microfluidic Hydrogel Microcapsules for Drug Evaluation. [PDF]
Adv Sci (Weinh), 2023 Chemotherapy is an essential postoperative treatment for pancreatic cancer, while due to the lack of effective drug evaluation platforms, the therapeutic outcomes are hampered by tumor heterogeneity among individuals.
Song T, Zhang H, Luo Z, Shang L, Zhao Y.
europepmc +2 more sources
Construction of Non-infectious SARS-CoV-2 Replicons and Their Application in Drug Evaluation. [PDF]
Virol Sin, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating pandemic worldwide. Vaccines and antiviral drugs are the most promising candidates for combating this global epidemic, and scientists all over the world have made great
Wang B +6 more
europepmc +2 more sources
Foods, 2021 A rapid and simple analytical method for triflumezopyrim, a new class of mesoionic insecticides and commercialized molecules from DuPont, was developed with a modified QuEChERS method.
Sung-Min Cho +9 more
doaj +1 more source
Decoding kinase-adverse event associations for small molecule kinase inhibitors
Nature Communications, 2022 Small molecule kinase inhibitors (SMKIs) are being approved at a fast pace under expedited programs for anticancer treatment. Here, the authors employ a machine-learning model to examine the relationships between kinase targets and adverse events in the ...
Xiajing Gong +8 more
doaj +1 more source
Rewarding and Reinforcing Effects of 25H-NBOMe in Rodents
Brain Sciences, 2022 The drug 25H-NBOMe is a new psychoactive substance (NPS). The use of these substances is likely to pose a threat to public health because they elicit effects similar to those of known psychoactive substances with similar chemical structures.
Cheolmin Jo +8 more
doaj +1 more source
Applied Biological Chemistry, 2023 In this study, an analysis method was established for the quantification of residues of halquinol and its metabolites in livestock and fishery products using liquid chromatography–tandem mass spectrometry (LC–MS/MS).
Tae Ho Lee +4 more
doaj +1 more source
Journal of Analytical Methods in Chemistry, 2022 Chinese medicine extracts are complex in composition. The combination of the quantitative analysis of multicomponents by single marker (QAMS) and the systematic quantified fingerprint method (SQFM) can be used for better quantitative analysis.
Long Chen +4 more
doaj +1 more source
Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation. [PDF]
Nat Commun, 2019 Hepatitis delta virus (HDV) depends on the helper function of hepatitis B virus (HBV), which provides the envelope proteins for progeny virus secretion. Current infection-competent cell culture models do not support assembly and secretion of HDV.
Lempp FA +7 more
europepmc +2 more sources
Considerations on Clinical Development and Regulatory of the Oversea License-in Anti-tumor Drugs
Chinese Journal of Lung Cancer, 2022 With the boom of China's innovative pharmaceutical industry, licensing-in model has gradually become an important research and development model for innovative pharmaceutical companies.
Xiao ZHAO +7 more
doaj +1 more source