Results 41 to 50 of about 19,912,299 (390)

DKK1 inhibits breast cancer cell migration and invasion through suppression of β-catenin/MMP7 signaling pathway

Cancer Cell International, 2019
Background DKK1 has been reported to act as a tumor suppressor in breast cancer. However, the mechanism of DKK1 inhibits breast cancer migration and invasion was still unclear.
Jie Niu, Xiao-Meng Li, Xiao Wang, Chao Liang, Yi-Dan Zhang, Hai-Ying Li, Fan-Ye Liu, Hua Sun, Song-Qiang Xie, Dong Fang   +9 more
doaj   +1 more source

Hydrogels as Drug Delivery Systems: A Review of Current Characterization and Evaluation Techniques

Pharmaceutics, 2020
Owing to their tunable properties, controllable degradation, and ability to protect labile drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a lack of standardized methodologies used to characterize and evaluate drug
Margaux Vigata, Christoph Meinert, D. Hutmacher, N. Bock   +3 more
semanticscholar   +1 more source

Public feedback to FDA on regulatory considerations for AI in drug manufacturing

AAPS Open
FDA’s Center for Drug Evaluation and Research (CDER) established the Framework for Regulatory Advanced Manufacturing Evaluation (FRAME) initiative to establish a regulatory framework to support the adoption of advanced manufacturing technologies that ...
Jayanti Das, Thomas F. O’Connor, Adam C. Fisher, Manuel Osorio, Johnny Lam, Riley C. Myers   +5 more
doaj   +1 more source

The complete chloroplast genome sequence of three medicinal species; Curcuma longa, Curcuma wenyujin, and Curcuma phaeocaulis (Zingiberaceae)

Mitochondrial DNA. Part B. Resources, 2021
Curcuma longa, C. wenyujin and C. phaeocaulis are important herbal medicine which of rhizomatous herbaceous perennial plant of the family Zingiberaceae.
Min-Kyeoung Kim, Woo Kyu Lee, Yoo Rae Choi, Jonghwan Kim, Ilhyun Kang, Juhye Kang   +5 more
doaj   +1 more source

Risk Perception and Drug Safety Evaluation [PDF]

, 1991
The authors present a Risk communication framework based on a survey of empirical research concerning public Risk perceptions.
Vertinsky, Ilan B., Wehrung, Donald A.
core   +1 more source

Cost-effectiveness of Methadone Maintenance Treatment in prevention of HIV among drug users in Shiraz, south of Iran [PDF]

, 2014
Background: The increase in high-risk injections and unsafe sexual behaviors has led to increased HIV infection prevalence among Intravenous Drug Users (IDUs). The high costs of HIV/AIDS care and low financial resources necessitate an economic evaluation
Heidari, A., Javanbakht, M., Keshtkaran, A., Mirahmadizadeh, A.   +3 more
core   +1 more source

Safety and Efficacy of Anticoagulation Therapy in Paediatric Patients With Solid Tumours or Lymphomas at Risk of Thrombocytopenia: A Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with solid tumours or lymphomas have an increased risk of thromboembolism (TE) and thrombocytopenia. Evidence‐based strategies for anticoagulation therapy (ACT) for patients with thrombocytopenia are limited. We examined the impact of thrombocytopenia on ACT administration and bleeding incidence in children with solid ...
Andrés Felipe Fajardo, Katherine Talpin, Bishal Harry, Uma H. Athale, Anthony K. C. Chan, Mihir D. Bhatt   +5 more
wiley   +1 more source

Quantitative analysis method for isoeugenol in fishery products using gas chromatography–tandem mass spectrometry

Applied Biological Chemistry
Isoeugenol, an anesthetic used in marine products, has different regulations in each country and there is controversy regarding the degree of risk. Therefore, it is necessary to establish reliable analytical methods for detection and quantification.
Ye-Bin Jang, Yeong-Ju Jo, Mi-ok Kim, Gui-Hyun Jang   +3 more
doaj   +1 more source

MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge

npj Vaccines, 2021
Numerous vaccine candidates against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are under development. The majority of vaccine candidates to date are designed to induce immune responses against the viral spike (S) protein, although ...
Clement A. Meseda, Charles B. Stauft, Prabhuanand Selvaraj, Christopher Z. Lien, Cyntia Pedro, Ivette A. Nuñez, Amy M. Woerner, Tony T. Wang, Jerry P. Weir   +8 more
doaj   +1 more source

Utilizing Multi-level Classification Techniques to Predict Adverse Drug Effects and Reactions [PDF]

, 2019
Multi-class classification models are used to predict categorical response variables with more than two possible outcomes. A collection of multi-class classification techniques such as Multinomial Logistic Regression, Na\ {i}ve Bayes, and Support Vector ...
Puhl, Victoria
core   +1 more source