Results 71 to 80 of about 18,950,887 (401)

Characterization of Formononetin Sulfonation in SULT1A3 Overexpressing HKE293 Cells: Involvement of Multidrug Resistance-Associated Protein 4 in Excretion of Sulfate

Frontiers in Pharmacology, 2021
Formononetin is one of the main active compounds of traditional Chinese herbal medicine Astragalus membranaceus. However, disposition of formononetin via sulfonation pathway remains undefined.
Fanye Liu, Shuhua Pei, Wenqi Li, Xiao Wang, Chao Liang, Ruohan Yang, Zhansheng Zhang, Xin Yao, Dong Fang, Songqiang Xie, Hua Sun   +10 more
doaj   +1 more source

Evaluation and Prediction of Drug Permeation

Journal of Pharmacy and Pharmacology, 1999
Abstract A major challenge confronting the pharmaceutical scientist is to optimize the selective and efficient delivery of new active entities and drug candidates. Successful drug development requires not only optimization of specific and potent pharmacodynamic activity, but also efficient delivery to the target site.
Pagliara, Alessandra, Reist, Marianne, Geinoz, S., Carrupt, Pierre-Alain, Testa, Bernard   +4 more
openaire   +3 more sources

Postmarketing Evaluation of Drugs [PDF]

Therapies, 2003
Abstract Round table no. 2 was devoted to the postmarketing evaluation of drugs. The debates involved both the questions posed by postmarketing evaluation and the methods for responding to them. The major categories of questions likely to be posed are as follows: efficacy in actual situations; safety in actual situations; prognostic factors and ...
Gérard Bréart, C. Duguay, F. de Cremiers, S. Tardieu, M.N. Banzet, Jean-Pierre Daurès, Jacques Massol, Jean-Marie Goehrs, A. Rauss, A. Fontbonne-Bayner, S. Paulmier-Bigot, Eveline Eschwège, Joëlle Micallef, J.M. Vetel, R. Koen, D. Vesque, François Meyer, E. Leutenegger, F. Ichou, P. Watteau, M. Bouhassira, Abdelkader El Hasnaoui, P.F. Ploin, Jean-Michel Joubert, Patrick Blin, Pascale Jolliet, Catherine Le Galès, D. Lagarde, Isabelle Giri, M. Ricatte, T. Marquet, Y. Ract, Muriel Vray, Francis Fagnani, J.M. Hotton, H. Sainte-Marie, C. Blachier, C. Le Jeunne, Gilles Bouvenot   +38 more
openaire   +2 more sources

The Minnesota Supportive Housing and Managed Care Pilot: Evaluation Summary [PDF]

, 2010
Summarizes an evaluation of a pilot program to end homelessness for those with complex needs by providing housing and intensive supports. Examines outcomes including housing stability, mental health, and alcohol and/or drug use, as well as service ...

core  

Geriatric pharmacotherapy : optimisation through integrated approach in the hospital setting [PDF]

, 2016
Since older patients are more vulnerable to adverse drug-related events, there is a need to ensure appropriate prescribing in these patients in order to prevent misuse, overuse and underuse of drugs.
A Corsonello, A Jha, A Leendertse, A Somers, A Somers, A Somers, A Spinewine, A Spinewine, A Spinewine, American Geriatrics Society, B Basger, B Berenguer, B Lund, B Strom, B Tangiisuran, C Lindley, C Naugler, C Rancourt, C Scullin, C Zhan, D Classen, E Hajjar, G Batty, G Ellis, G Onder, G Onder, G Onder, G Onder, H Beijer, H Hamilton, I Eland, J Hanlon, J Hanlon, J Klopotowska, J Lazarou, J Schnipper, J Wolfstadt, K Perehudoff, K Schmader, L Leape, M Beers, M Laroche, M O’Connor, M Passarelli, M Petrovic, M Petrovic, M Pirmohamed, M Steinman, NS Wenger, P Bemt van den, P Gallagher, P Gallagher, P Lampela, P McLeod, P Rochon, R Cipolle, R Page, S Holt, S Kaur, S Kucukarslan, S Rognstad, T Field, T Field, W Winit-Watjana   +63 more
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation

European Respiratory Journal, 2013
Research into the pathogenesis underlying the development of idiopathic pulmonary fibrosis is hampered by a repertoire of animal models that fail to recapitulate all the features of the human disease.
C. Scotton, Brian Hayes, R. Alexander, Arnab Datta, E. Forty, P. Mercer, A. Blanchard, R. Chambers   +7 more
semanticscholar   +1 more source

Drug usage evaluation of dapsone

Indian Journal of Pharmaceutical Sciences, 2009
Dapsone has been the principal drug in a multidrug regimen recommended by the World Health Organization for the treatment of leprosy. It is also widely used by dermatologists in varied skin conditions like dermatitis herpetiformis, bullous pemphigoid, Behcet's disease, lupus erythematous and a host of other skin diseases. Hence an attempt has been made
J. Vasantha, N Vanitha Rani, K Kousalya, G Kannan, C. Uma Maheswara Reddy, P Thennarasu, P Anuradha   +6 more
openaire   +4 more sources

Juvenile substance use and effects of substance use disorder on incarceration and grade retention in a sample referred for court clinic mental health evaluation [PDF]

, 2015
A significant amount of adolescents are involved in the drug court system. Within a few of the systems are mental health clinics providing more specific services to youth introduced into the courts.
Oliveira, Cassandra
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source