Results 181 to 190 of about 3,996,783 (390)

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Drug Hypersensitivity Associated with Dental Treatments

Pesquisa Brasileira em Odontopediatria e Clínica Integrada
Objective: To characterize drug hypersensitivity associated with dental treatments. Material and Methods: Data from 5,302 dental patients extracted from the Faculty of Dental Medicine were used to investigate drug use history, drug hypersensitivity, and ...
Ricardo Dias de Castro, Mariana Bezamat, Alexandre Rezende Vieira   +2 more
doaj  

Repurposing HLA genotype data of renal transplant patients to prevent severe drug hypersensitivity reactions. [PDF]

Front Genet, 2023
Manson LEN, Delwig SJ, Drabbels JJM, Touw DJ, De Vries APJ, Roelen DL, Guchelaar HJ.   +6 more
europepmc   +1 more source

Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations [PDF]

, 2003
Werner Aberer, Andreas J. Bircher, Antonino Romano, M. Blanca, Paolo Campi, Javier Fernández, Knut Brockow, Werner J. Pichler, Pascal Demoly   +8 more
openalex   +1 more source

Pharmacokinetic and Bioequivalence Evaluation of Two Sitagliptin Tablets With Different Salts in Healthy Subjects

Clinical Pharmacology in Drug Development, EarlyView.
Abstract The objective of the current study was to evaluate the rate and extent of absorption of a test formulation (sitagliptin hydrochloride) and a reference formulation (sitagliptin phosphate). An open‐label, randomized, single‐dose, single‐center, 2‐sequence, 2‐period, and cross‐over phase 1 study was implemented to assess the pharmacokinetic ...
Usok Hyun, Seongnam Chu, Sungyun Kim, Jung‐Ki Hong, Taeyoung Kim, In‐Soo Yoon, Jung‐Jin Kim, Hyun‐Jong Cho   +7 more
wiley   +1 more source

Concordance of gout management with European League against Rheumatism recommendations in hospital practice [PDF]

, 2010
Aim: To assess the concordance of gout management with the European League Against Rheumatism (EULAR) gout recommendations in hospital practice. Methods: This was a retrospective review of case notes of patients presenting to rheumatology outpatients ...
Attard Cortis, Petramay, Borg, Andrew A., Coleiro, Bernard, Mercieca, Cecilia   +3 more
core  

Hypersensitivity to nonsteroidal antiinflammatory drugs: Indications and methods for oral challenges

, 1979
David A. Mathison, Donald D. Stevenson
openalex   +1 more source

Characterization of drug-specific T cells in lamotrigine hypersensitivity [PDF]

, 2003
Dean J. Naisbitt, John Farrell, Gavin Wong, Jan P.H. Depta, Charlotte C. Dodd, Josephine E. Hopkins, Claire A. Gibney, David Chadwick, Werner J. Pichler, Munir Pirmohamed, B.Kevin Park   +10 more
openalex   +1 more source

Spotlight commentary: Treatment of multidrug‐resistant Gram‐negative infections in the era of growing antimicrobial resistance

British Journal of Clinical Pharmacology, EarlyView.
Luka Bielen, Andro Vujević, Luka Csenar
wiley   +1 more source

Safety, Tolerability, and Pharmacokinetics of the Long‐Acting SARS‐CoV‐2–Neutralizing Monoclonal Antibody Combination AZD7442 (Tixagevimab/Cilgavimab) in Healthy Chinese Adults

Clinical Pharmacology in Drug Development, EarlyView.
Abstract AZD7442, a combination of extended half‐life monoclonal antibodies tixagevimab and cilgavimab, was shown to neutralize previously circulating SARS‐CoV‐2 variants. This study evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD7442 in healthy Chinese adults. In this randomized, placebo‐controlled, Phase 1 study, AZD7442
Nanyang Li, Jing Zhang, Wenhong Zhang, Zhongyuan Xu, Xiangcao Yao, Anqi He, Shuyuan Liu, Xiaoyun Ge, Jinxi Liu, Yunfei Li, Cecil Chi‐Keung Chen, Huixia Zhang   +11 more
wiley   +1 more source