Results 21 to 30 of about 4,080,452 (353)

Update on pathobiology in Stevens-Johnson syndrome and toxic epidermal necrolysis

Dermatologica Sinica, 2013
Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) are rare but life-threatening severe cutaneous adverse reactions (SCARs), which are mainly induced by a variety of drugs. Once considered to be unpredictable, significant progress has been
Shih-Chi Su, Wen-Hung Chung
doaj   +1 more source

Self-report prevalence and associated factors to drug hypersensitivity in Mexican young adults [PDF]

, 2017
Background: Drug hypersensitivity is defined as any unfavorable reaction that occurs after the administration of any drug. It may or may not be mediated by the involvement of the immune system.
BEDOLLA BARAJAS, MARTIN, BEDOLLA BARAJAS, MARTIN, DOMINGUEZ GARCIA, MA VICTORIA, DOMINGUEZ GARCIA, MA VICTORIA, FLORES MERINO, MIRIAM VERONICA, FLORES MERINO, MIRIAM VERONICA, MORALES ROMERO, JAIME, MORALES ROMERO, JAIME, PUENTE FERNANDEZ, CECILIA, PUENTE FERNANDEZ, CECILIA   +9 more
core   +1 more source

Cytotoxic Proteins and Therapeutic Targets in Severe Cutaneous Adverse Reactions

Toxins, 2014
Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are rare but life-threatening conditions induced mainly by a variety of drugs.
Shih-Chi Su, Wen-Hung Chung
doaj   +1 more source

Proteomics in drug hypersensitivity [PDF]

, 2016
21 p.-4 fig.-1 tab.Drug hypersensitivity reactions result from the activation of the immune system by drugs or their metabolites. The clinical presentations of drug hypersensitivity can range from relatively mild local manifestations to severe systemic ...
Aldini, Giancarlo, González-Morena, Juan M., Montañez, M. I., Pérez-Sala, Dolores, Sánchez-Gómez, Francisco J.   +4 more
core   +1 more source

MRGPRX2 and Immediate Drug Hypersensitivity: Insights from Cultured Human Mast Cells.

Journal of investigational allergology & clinical immunology, 2020
BACKGROUND AND OBJECTIVE Mast cell (MC) degranulation via activation of the Mas-related G protein-coupled receptor X2 (MRGPRX2) is held to be of key importance for immediate drug hypersensitivity (IDH). However, data in humans are limited to observations
J. Elst, V. Sabato, M. Faber, C. Bridts, Christel M Mertens, M. V. Houdt, A. L. Gasse, M. Hagendorens, V. V. Tendeloo, M. Maurer, D. Campillo-Davo, J. Timmermans, I. Pintelon, D. Ebo   +13 more
semanticscholar   +1 more source

Acute generalized exanthematous pustulosis: A retrospective study of 51 cases in Taiwan

Dermatologica Sinica, 2014
Background/Objective: Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse drug reaction characterized by fever and numerous sterile non-follicular pustules.
Yung-Yi Lee, Wen-Hung Chung
doaj   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Drug hypersensitivity reactions in Asia: regional issues and challenges

Asia Pacific Allergy, 2020
There are geographical, regional, and ethnic differences in the phenotypes and endotypes of patients with drug hypersensitivity reactions (DHRs) in different parts of the world. In Asia, aspects of drug hypersensitivity of regional importance include IgE-
B. Thong, M. Lucas, Hye‐Ryun Kang, Yoon-Seok Chang, P. Li, M. Tang, J. Yun, J. S. Fok, Byung-Keun Kim, M. Nagao, I. Rengganis, Y. Tsai, W. Chung, M. Yamaguchi, T. Rerkpattanapipat, Wasu Kamchaisatian, T. Leung, H. Yoon, Luo Zhang, A. Latiff, T. Fujisawa, F. Thien, M. Castells, P. Demoly, Jiu-Yao Wang, R. Pawankar   +25 more
semanticscholar   +1 more source

Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Coronavirus disease 2019 (COVID‐19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from asymptomatic cases to patients ...
A. Gelincik, K. Brockow, G. Celik, I. Doña, L. Mayorga, A. Romano, Ö. Soyer, M. Atanasković-Marković, A. Barbaud, M. Torres   +9 more
semanticscholar   +1 more source

Neonatal lupus erythematosus presenting as Stevens-Johnson syndrome

Dermatologica Sinica, 2018
Neonatal lupus erythematosus (NLE) is a rare acquired condition caused by the transplacental passage of maternal autoantibodies. It is characterized by cutaneous, cardiac, hepatobiliary, hematological and neurological involvement.
Ren-Feng Liu, Wen-Hung Chung, Chin-Yi Yang, Fang-Ying Wang, Chun-Bing Chen   +4 more
doaj   +1 more source