Results 21 to 30 of about 3,966,363 (347)

MRGPRX2 and Immediate Drug Hypersensitivity: Insights from Cultured Human Mast Cells.

Journal of investigational allergology & clinical immunology, 2020
BACKGROUND AND OBJECTIVE Mast cell (MC) degranulation via activation of the Mas-related G protein-coupled receptor X2 (MRGPRX2) is held to be of key importance for immediate drug hypersensitivity (IDH). However, data in humans are limited to observations
J. Elst, V. Sabato, M. Faber, C. Bridts, Christel M Mertens, M. V. Houdt, A. L. Gasse, M. Hagendorens, V. V. Tendeloo, M. Maurer, D. Campillo-Davo, J. Timmermans, I. Pintelon, D. Ebo   +13 more
semanticscholar   +1 more source

Update on pathobiology in Stevens-Johnson syndrome and toxic epidermal necrolysis

Dermatologica Sinica, 2013
Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) are rare but life-threatening severe cutaneous adverse reactions (SCARs), which are mainly induced by a variety of drugs. Once considered to be unpredictable, significant progress has been
Shih-Chi Su, Wen-Hung Chung
doaj   +1 more source

Acute generalized exanthematous pustulosis: A retrospective study of 51 cases in Taiwan

Dermatologica Sinica, 2014
Background/Objective: Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse drug reaction characterized by fever and numerous sterile non-follicular pustules.
Yung-Yi Lee, Wen-Hung Chung
doaj   +1 more source

Cytotoxic Proteins and Therapeutic Targets in Severe Cutaneous Adverse Reactions

Toxins, 2014
Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are rare but life-threatening conditions induced mainly by a variety of drugs.
Shih-Chi Su, Wen-Hung Chung
doaj   +1 more source

Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Coronavirus disease 2019 (COVID‐19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from asymptomatic cases to patients ...
A. Gelincik, K. Brockow, G. Celik, I. Doña, L. Mayorga, A. Romano, Ö. Soyer, M. Atanasković-Marković, A. Barbaud, M. Torres   +9 more
semanticscholar   +1 more source

Drug hypersensitivity reactions in Asia: regional issues and challenges

Asia Pacific Allergy, 2020
There are geographical, regional, and ethnic differences in the phenotypes and endotypes of patients with drug hypersensitivity reactions (DHRs) in different parts of the world. In Asia, aspects of drug hypersensitivity of regional importance include IgE-
B. Thong, M. Lucas, Hye‐Ryun Kang, Yoon-Seok Chang, P. Li, M. Tang, J. Yun, J. S. Fok, Byung-Keun Kim, M. Nagao, I. Rengganis, Y. Tsai, W. Chung, M. Yamaguchi, T. Rerkpattanapipat, Wasu Kamchaisatian, T. Leung, H. Yoon, Luo Zhang, A. Latiff, T. Fujisawa, F. Thien, M. Castells, P. Demoly, Jiu-Yao Wang, R. Pawankar   +25 more
semanticscholar   +1 more source

Hypersensitivity to antiretroviral drugs [PDF]

European Annals of Allergy and Clinical Immunology, 2018
Background. Antiretroviral therapy (ART) may be responsible for hypersensitivity reactions varying in severity, clinical manifestations and frequency. Case report. We report the case of a 47-year-old woman with HIV infection who developed a delayed mucocutaneous reaction after treatment with ART.
Thayna Teixeira, Susana Cadinha, M. Mota, Maria João Sousa, J.P. Moreira da Silva, Daniela Malheiro   +5 more
openaire   +3 more sources

Neonatal lupus erythematosus presenting as Stevens-Johnson syndrome

Dermatologica Sinica, 2018
Neonatal lupus erythematosus (NLE) is a rare acquired condition caused by the transplacental passage of maternal autoantibodies. It is characterized by cutaneous, cardiac, hepatobiliary, hematological and neurological involvement.
Ren-Feng Liu, Wen-Hung Chung, Chin-Yi Yang, Fang-Ying Wang, Chun-Bing Chen   +4 more
doaj   +1 more source

Practical Approach to Hypersensitivity to Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Children

Pharmaceuticals, 2023
Background: We aimed to assess the real-life prevalence, patient profile, and clinical presentation of drug hypersensitivity to NSAIDs in children after an incidence of an adverse event during treatment, verified by a drug challenge test.
Daniela Podlecka, Anna Socha-Banasiak, Joanna Jerzynska, Joanna Nodzykowska, Agnieszka Brzozowska   +4 more
doaj   +1 more source

Diagnostic Test Criteria for HLA Genotyping to Prevent Drug Hypersensitivity Reactions: A Systematic Review of Actionable HLA Recommendations in CPIC and DPWG Guidelines

Frontiers in Pharmacology, 2020
Introduction Certain HLA variants are associated with an increased risk of hypersensitivity reactions to specific drugs. Both the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG) have issued ...
Lisanne E N Manson, J. Swen, H. Guchelaar   +2 more
semanticscholar   +1 more source