The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. [PDF]
, 2013 Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases.
Czimmer, József +7 more
core +7 more sources
Hypersensitivity reactions to small molecule drugs
Frontiers in Immunology, 2022 Drug hypersensitivity reactions induced by small molecule drugs encompass a broad spectrum of adverse drug reactions with heterogeneous clinical presentations and mechanisms.
Jiayin Han +6 more
doaj +1 more source
Update on pathobiology in Stevens-Johnson syndrome and toxic epidermal necrolysis
Dermatologica Sinica, 2013 Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) are rare but life-threatening severe cutaneous adverse reactions (SCARs), which are mainly induced by a variety of drugs. Once considered to be unpredictable, significant progress has been
Shih-Chi Su, Wen-Hung Chung
doaj +1 more source
MRGPRX2 and Immediate Drug Hypersensitivity: Insights from Cultured Human Mast Cells.
Journal of investigational allergology & clinical immunology, 2020 BACKGROUND AND OBJECTIVE Mast cell (MC) degranulation via activation of the Mas-related G protein-coupled receptor X2 (MRGPRX2) is held to be of key importance for immediate drug hypersensitivity (IDH). However, data in humans are limited to observations
J. Elst +13 more
semanticscholar +1 more source
Cytotoxic Proteins and Therapeutic Targets in Severe Cutaneous Adverse Reactions
Toxins, 2014 Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are rare but life-threatening conditions induced mainly by a variety of drugs.
Shih-Chi Su, Wen-Hung Chung
doaj +1 more source
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]
, 2012 Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas +47 more
core +4 more sources
Allergy. European Journal of Allergy and Clinical Immunology, 2020 Coronavirus disease 2019 (COVID‐19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from asymptomatic cases to patients ...
A. Gelincik +9 more
semanticscholar +1 more source
Acute generalized exanthematous pustulosis: A retrospective study of 51 cases in Taiwan
Dermatologica Sinica, 2014 Background/Objective: Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse drug reaction characterized by fever and numerous sterile non-follicular pustules.
Yung-Yi Lee, Wen-Hung Chung
doaj +1 more source
Proteomics in drug hypersensitivity [PDF]
, 2016 21 p.-4 fig.-1 tab.Drug hypersensitivity reactions result from the activation of the immune system by drugs or their metabolites. The clinical presentations of drug hypersensitivity can range from relatively mild local manifestations to severe systemic ...
Aldini, Giancarlo +4 more
core +1 more source
Drug hypersensitivity reactions in Asia: regional issues and challenges
Asia Pacific Allergy, 2020 There are geographical, regional, and ethnic differences in the phenotypes and endotypes of patients with drug hypersensitivity reactions (DHRs) in different parts of the world. In Asia, aspects of drug hypersensitivity of regional importance include IgE-
B. Thong +25 more
semanticscholar +1 more source