Results 11 to 20 of about 2,423,182 (300)
Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study [PDF]
, 2005 Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle.
McKinnon, E. +11 more
core +2 more sources
Update on pathobiology in Stevens-Johnson syndrome and toxic epidermal necrolysis
Dermatologica Sinica, 2013 Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) are rare but life-threatening severe cutaneous adverse reactions (SCARs), which are mainly induced by a variety of drugs. Once considered to be unpredictable, significant progress has been
Shih-Chi Su, Wen-Hung Chung
doaj +1 more source
Hypersensitivity reactions to small molecule drugs
Frontiers in Immunology, 2022 Drug hypersensitivity reactions induced by small molecule drugs encompass a broad spectrum of adverse drug reactions with heterogeneous clinical presentations and mechanisms.
Jiayin Han +6 more
doaj +1 more source
Acute generalized exanthematous pustulosis: A retrospective study of 51 cases in Taiwan
Dermatologica Sinica, 2014 Background/Objective: Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse drug reaction characterized by fever and numerous sterile non-follicular pustules.
Yung-Yi Lee, Wen-Hung Chung
doaj +1 more source
Cytotoxic Proteins and Therapeutic Targets in Severe Cutaneous Adverse Reactions
Toxins, 2014 Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are rare but life-threatening conditions induced mainly by a variety of drugs.
Shih-Chi Su, Wen-Hung Chung
doaj +1 more source
Multiple Drug Hypersensitivity [PDF]
International Archives of Allergy and Immunology, 2017 Multiple drug hypersensitivity (MDH) is a syndrome that develops as a consequence of massive T-cell stimulations and is characterized by long-lasting drug hypersensitivity reactions (DHR) to different drugs. The initial symptoms are mostly severe exanthems or drug rash with eosinophilia and systemic symptoms (DRESS).
Werner J, Pichler +3 more
openaire +2 more sources
Neonatal lupus erythematosus presenting as Stevens-Johnson syndrome
Dermatologica Sinica, 2018 Neonatal lupus erythematosus (NLE) is a rare acquired condition caused by the transplacental passage of maternal autoantibodies. It is characterized by cutaneous, cardiac, hepatobiliary, hematological and neurological involvement.
Ren-Feng Liu +4 more
doaj +1 more source
Drug hypersensitivity syndrome
Indian Journal of Dermatology, Venereology, and Leprology, 2011 Drug hypersensitivity syndrome (DHS) is an adverse drug reaction commonly associated with the aromatic antiepileptic drugs (AEDs), viz., phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), lamotrigine, primidone, etc. It can also be caused by other drugs, such as sulfonamides, dapsone, minocycline, gold derivatives, cyclosporine, captopril ...
Kumari, Rashmi +2 more
openaire +2 more sources
Journal of Immunology Research, 2020 Adult-onset Still’s disease (AOSD) is a rare and inflammatory disorder characterized by spiking fever, rash, arthritis, and multisystemic involvement. HLA has been shown to be associated with AOSD; however, it could not explain the innate immunity and ...
Yi-Ming Chen +9 more
doaj +1 more source
Drug Hypersensitivity: Diagnosis, Genetics, and Prevention [PDF]
Deutsches Ärzteblatt international, 2018 Adverse drug reactions (ADRs) can be divided into pharmacological ADRs (type A) and hypersensitivity reactions (type B). Type B reactions can be further subdivided into immediate (1 h, variable manifestation like exanthema, hepatitis, cytopenias). Prevention of hypersensitivity is often still a challenge.Selective literature search in Medline and ...
Ruwen, Böhm +3 more
openaire +2 more sources