Results 31 to 40 of about 2,423,182 (300)
Clinical Characteristics and Disease Burden of Patients with Moderate-to-Severe Generalized Pustular Psoriasis Flares in Taiwan
Dermatology and TherapyIntroduction Generalized pustular psoriasis (GPP) is a rare and severe psoriasis subtype characterized by the rapid onset of coalescing sterile pustules over broad body areas and systemic inflammation.Chun-Wei Lu, Chien-Yu Tseng, Chuang-Wei Wang, Shang-Hung Lin, Chun-Bing Chen, Rosaline Chung-Yee Hui, Ching-Chi Chi, Yu-Huei Huang, Chih-Hung Lee, Fang-Ju Lin, Wen-Hung Chung +10 moredoaj +1 more sourceNew Approaches to Investigate Drug-Induced Hypersensitivity [PDF]
, 2016 The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and ...Norris, Alan, Park, Brian Kevin, Hirschfield, Gideon M., French, Neil, Gibson, Andrew, Dickinson, Anne, Musette, Philippe, Betts, Catherine J, Purcell, Anthony Wayne, Pirmohamed, Munir, Martin, Stefan F, Kammueller, Michael, Martin, Stefan F., Alferivic, Ana, Alfirevic, Ana, Naisbitt, Dean J., Spraggs, Colin F., Hirschfield, Gideon M, Park, B. Kevin, Ogese, Monday O., Spraggs, Colin F, Naisbitt, Dean John, Whritenour, Jessica, Ogese, Monday O, Kammüller, Michael Ernst, Ahmed, Shaheda, Faulkner, Lee, Purcell, Anthony W., French, Neil S, Meng, Xiaoli, Betts, Catherine J., Ahmed S, Whritenour J, Ogese MO, Hirschfield GM, Spraggs CF, Martin SF, Purcell AW, Kammüller M, Musette P, Naisbitt, Dean J, Gibson A, Betts CJ, Park, B Kevin, Naisbitt DJ, Norris A, French N, Meng X, Faulkner L, Purcell, Anthony W, Kammuller, Michael, Alferivic A, Dickinson A, Pirmohamed M, Park BK +54 morecore +1 more sourceImmune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade
Nature CommunicationsImmune checkpoint inhibitors (ICI) represent new anticancer agents and have been used worldwide. However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epidermal necrolysis ...Chun-Bing Chen, Shuen-Iu Hung, John Wen-Cheng Chang, Chan-Keng Yang, David Hui-Kang Ma, Yu-Chuan Teng, Chun-Wei Lu, Wei-Ti Chen, Hsiao-Yin Yang, Cheng-Chang Tsai, Chih Liang Wang, Pin-Hsuan Chiang, Jennifer Wu, Ya-Wen Tsai, Lai-Ying Lu, Yang Yu-Wei Lin, Rosaline Chung-Yee Hui, Fu-Mei Hsieh, Chao-Kai Hsu, Chaw-Ning Lee, Yi-Ju Chen, Chih-Chiang Chen, Yilei Cui, Hung-Chih Hsu, Ya-Ching Chang, Chih-Jung Chang, Ho-Chen Lin, Chee Jen Chang, Yu-Jr Lin, Cheng-Lung Ku, Chuang-Wei Wang, Wen-Hung Chung +31 moredoaj +1 more sourceSPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin +17 morewiley +1 more sourceGeneral considerations on rapid desensitization for drug hypersensitivity - a consensus statement
, 2010 Drug hypersensitivity reactions can occur with most drugs, are unpredictable, may affect any organ or system, and range widely in clinical severity from mild pruritus to anaphylaxis. In most cases, the suspected drug is avoided in the future.Bircher, A., Sanz, M. L., Romano, A., Campi, P., Cernadas, J. R., Aberer, W., Castells, M., Torres, M. J., the EAACI interest group on drug hypersensitivity,, Brockow, K., for the European Network of Drug Allergy,, Pichler, Werner Joseph, Demoly, P. +12 morecore +2 more sourcesPharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project
, 2009 Nonallergic hypersensitivity and allergic reactions are part of the many different types of adverse drug reactions (ADRs). Databases exist for the collection of ADRs.Kowalski ML, Kowalski, M. L., Zuberbier T, Canonica, G. W., Bousquet, P-J, Burney, P G, Ponvert C, Demoly, P, Salapatas, M., Demoly, P., Aberer, W, Terreehorst, I, Arnoux, B., Martins, P., Gueant, J. L., Sidoroff A, Bonadonna P, Mertes, P-M, Barbaud A, Drug Allergy, Martins, P, Pirmohamed, M, Merk, H F, Ring, J, Szczeklik A, Torres, M. J., Martins P, Gomes, E., Ponvert, C, Daures JP, Bircher A, Blanca, M., Sanz, M. L., Papadopoulos, N., Terreehorst, I., Barbaud, A, Sachs, B., Bijl, A, Gomes E, Aberer W, Dahlen, B, Van Ganse, E, Blanca M, Bijl A, Van Ganse E, Pirmohamed, M., Kvedariene, V, Mertes PM, Papadopoulos, N, Papadopoulos N, Zuberbier, Torsten, Burney, P. G., Fernandez J, the European Network for Drug Allergy, Arnoux B, Barbaud, A., Bonadonna, P, Pirmohamed M, Sachs B, Aberer, W., CANONICA, GIORGIO, Global Allergy, Asthma European Network (GALEN) and Drug Allergy and Hypersensitivity Database (DAHD) and the European Network for Drug Allergy (ENDA), Gueant JL, Bousquet, P. J., Atanaskovic-Markovic, M, Global Allergy Asthma European Network, Fernandez, J., Caimmi S, Bircher, A, Bousquet PJ, Romano, A., Romano, A, Caimmi, S., Mertes, P. M., Bijl, A., Szczeklik, A, Nizankowska Mogilnicka E, Merk, H. F., Gueant, J-L, Sidoroff, A, Ring J, Gomes, E, Pichler, W., Arnoux, B, Atanaskovic Markovic M, Cernadas J, Merk HF, Sachs, Bernhardt, Sidoroff, A., Walter Canonica, G., De Weck, A L, Zuberbier, T, Aberer, Werner, Romano A, Blanca, M, Nizankowska-Mogilnicka, E, Atanaskovic-Markovic, M., Sanz ML, Canonica, G W, Brockow, K., Caimmi, S, Zuberbier, T., Burney PG, Salapatas M, Kowalski, M L, Ponvert, C., Papadopoulos, N.; id_orcid, Dahlen B, Sanz, M L, Sachs, B, Merk, Hans, Szczeklik, A., Brockow, K, De Weck AL, Kvedariene V, Kvedariene, V., Pichler, W, Cernadas, J, Daures, J-P, Bircher, A., Terreehorst I, Torres, M J, Ring, J., Dahlen, B., Daures, J. P., Cernadas, J., Salapatas, M, Fernandez, J, Pichler W, Demoly P, Nizankowska-Mogilnicka, E., Hypersensitivity Database, Bonadonna, P., Brockow K, Torres MJ, van Ganse, E., de Weck, A. L., Pichler, Werner Joseph, Torres, MJ, Bousquet, PJ;Demoly, P;Romano, A;Aberer, W;Bircher, A;Blanca, M;Brockow, K;Pichler, W;Torres, MJ;Terreehorst, I;Arnoux, B;Atanaskovic-Markovic, M;Barbaud, A;Bijl, A;Bonadonna, P;Burney, PG;Caimmi, S;Canonica, GW;Cernadas, J;Dahlén, B;Daurès, JP;Fernandez, J;Gomes, E;Guéant, JL;Kowalski, ML;Kvedariene, V;Mertes, PM;Martins, P;Nizankowska-Mogilnicka, E;Papadopoulos, N;Ponvert, C;Pirmohamed, M;Ring, J;Salapatas, M;Sanz, ML;Szczeklik, A;Van Ganse, E;De Weck, AL;Zuberbier, T;Merk, HF;Sachs, B;Sidoroff, A +139 morecore +1 more sourceThe Mechanism of Onychomadesis (Nail Shedding) and Beau’s Lines Following Hand-Foot-Mouth Disease
Viruses, 2019 Background: Nail changes, including onychomadesis (nail shedding) and Beau’s line, following hand-foot-mouth disease (HFMD) are a common emergence at the stage of late complications of HFMD. However, the exact mechanism is still unknown. Therefore, Hsiu-Hui Chiu, Ming-Tsan Liu, Wen-Hung Chung, Yu-Shien Ko, Chin-Fang Lu, Cheng-Che E. Lan, Chun-Wei Lu, Kai-Che Wei +7 moredoaj +1 more source
