Results 21 to 30 of about 220,353 (256)

Effect of Implementing a Dashboard With or Without a Best Practice Alert on HLA‐B*58:01 Testing Rates Among Allopurinol Users at VA Medical Centers

Arthritis Care &Research, EarlyView.
Objective The American College of Rheumatology recommends HLA‐B*58:01 allele testing before the initiation of allopurinol, specifically among Asian and African American/Black patients, due to their increased risk for severe hypersensitivity reactions. However, testing rates remain low at many health care facilities.
Abimbola Fadairo‐Azinge, Gabriela Schmajuk, Sristi Sharma, Colleen P. Flanagan, Sara Faghihi‐Kashani, Ning Zhang, Mary A. Whooley   +6 more
wiley   +1 more source

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]

, 2011
Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen, Manuela G. Neuman, Paul A. Hwang, Radu M. Nanau   +3 more
core   +1 more source

Community Acquired Pneumonia [PDF]

, 2017
Community acquired pneumonia is discussed, including the pathophysiology, treatment, patient education, and nursing practice ...
Foering, Allison
core   +2 more sources

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme [PDF]

, 2008
Observation of adverse drug reactions during drug development can cause closure of the whole programme. However, if association between the genotype and the risk of an adverse event is discovered, then it might suffice to exclude patients of certain ...
Breiman, Breslow, Dudbridge, Díaz-Uriarte, Efron, Fielding, Genkin, Graven, Hastie, Izmirlian, Kelly, Lindley, Park, Ripley, Roses, Roses, Tibshirani, Troyanskaya, Wille, Xiong, Yuan, Zaykin   +21 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Food allergies in pregnant women: a study of prevalence in expecting mothers and association with neonatal outcomes [PDF]

, 2013
Thesis (M.A.)--Boston UniversityIntroduction: Food allergies, the second most common form of allergic disorders in Western countries, have been on the rise in the US over the past few decades especially in young children.
Seita, Helene M.
core   +1 more source

Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]

, 2005
The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati, Bagherieh-Najjar, Bai, Blackburn, Bundock, Cohen, Courcelle, Cromie, De Silva, Dellaporta, Ellis, Fitzgerald, Frei, Gallego, Gallego, Gallego, Gherbi, Gray, Hanada, Hanin, Harrigan, Hartung, Henson, Imamura, Jackson, Jacques Hille, Johnson, Kitao, Krysan, Li, Lovett, Lowndes, McGlynn, McHugh, Mengiste, Michel, Mohammad B. Bagherieh-Najjar, Nakayama, Nakayama, Nugent, Onno M.H. Vries, Osborn, Pastink, Paul P. Dijkwel, Pierce, Puchta, Reiss, Riha, Riha, Rothstein, Sambrook, Seigneur, Sengupta, Sessions, Simon, Sinclair, Sladek, Sundaresan, Swoboda, Tercero, Ui, Valvekens, Watt, Wu, Yamagata   +64 more
core   +3 more sources

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source