Results 51 to 60 of about 1,960,750 (298)

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source

Elevated liver enzymes is not an impediment to allopurinol dose escalation: an observational cohort study

Arthritis Care &Research, Accepted Article.
Objective Routine liver enzyme monitoring is advocated while on allopurinol but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzymes in gout patients commenced on allopurinol. Methods 150 patients with gout and normal baseline serum aminotransferases initiated on allopurinol were followed ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Efficacy and safety of indigo naturalis oil extract (Lindioil ointment) for the treatment of atopic dermatitis: a randomized, crossover, evaluator-blinded, controlled trial

Frontiers in Pharmacology
IntroductionLindioil ointment or its compound formulations are commonly used traditional Chinese medicine practitioners to treat adult eczema or localized dermatitis.
Chin-Yi Yang, Chin-Yi Yang, Chin-Yi Yang, Chin-Yi Yang, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Min-Hui Chi, Min-Hui Chi, Min-Hui Chi, Min-Hui Chi, Jennifer Wu, Jennifer Wu, Jennifer Wu, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Be-Han Lee, Yin-Ku Lin, Yin-Ku Lin   +24 more
doaj   +1 more source

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]

, 2011
Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen, Paul A. Hwang, Manuela G. Neuman, Radu M. Nanau   +3 more
core  

Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform : the Galenda project

, 2009
Nonallergic hypersensitivity and allergic reactions are part of the many different types of adverse drug reactions (ADRs). Databases exist for the collection of ADRs.
Bousquet, P.-J., Kowalski ML, Kowalski, M. L., Zuberbier T, Canonica, G. W., Bousquet, P-J, Burney, P G, Ponvert C, Demoly, P, Salapatas, M., Demoly, P., Gueant, J.-L., Aberer, W, Terreehorst, I, Arnoux, B., Martins, P., De Weck, A. L., Gueant, J. L., Sidoroff A, Bonadonna P, Mertes, P-M, Barbaud A, Drug Allergy, Martins, P, Pirmohamed, M, Merk, H F, Ring, J, Szczeklik A, Torres, M. J., Martins P, Gomes, E., Ponvert, C, Daures JP, Bircher A, Blanca, M., Sanz, M. L., Papadopoulos, N., Terreehorst, I., Barbaud, A, Sachs, B., Bijl, A, Gomes E, Aberer W, Dahlen, B, Van Ganse, E, Blanca M, Bijl A, Van Ganse E, Pirmohamed, M., Kvedariene, V, Mertes PM, Papadopoulos, N, Papadopoulos N, Zuberbier, Torsten, Burney, P. G., Fernandez J, the European Network for Drug Allergy, Arnoux B, Barbaud, A., Bonadonna, P, Pirmohamed M, Sachs B, Aberer, W., CANONICA, GIORGIO, Global Allergy, Asthma European Network (GALEN) and Drug Allergy and Hypersensitivity Database (DAHD) and the European Network for Drug Allergy (ENDA), Gueant JL, Bousquet, P. J., Atanaskovic-Markovic, M, Global Allergy Asthma European Network, Fernandez, J., Caimmi S, Bircher, A, Bousquet PJ, Romano, A., Romano, A, Caimmi, S., Mertes, P. M., Bijl, A., Szczeklik, A, Nizankowska Mogilnicka E, Merk, H. F., Gueant, J-L, Sidoroff, A, Ring J, Gomes, E, Pichler, W., Arnoux, B, Atanaskovic Markovic M, Cernadas J, Merk HF, Sachs, Bernhardt, Sidoroff, A., Walter Canonica, G., De Weck, A L, Zuberbier, T, Aberer, Werner, Romano A, Blanca, M, Nizankowska-Mogilnicka, E, Atanaskovic-Markovic, M., Sanz ML, Canonica, G W, Brockow, K., Caimmi, S, Zuberbier, T., Van Ganse, E., Burney PG, Salapatas M, Kowalski, M L, Ponvert, C., Papadopoulos, N.; id_orcid, Dahlen B, Sanz, M L, Sachs, B, Merk, Hans, Szczeklik, A., Brockow, K, De Weck AL, Kvedariene V, Kvedariene, V., Pichler, W, Mertes, P.-M., Daures, J.-P., Cernadas, J, Daures, J-P, Bircher, A., Terreehorst I, Torres, M J, Ring, J., Dahlen, B., Daures, J. P., Cernadas, J., Salapatas, M, Fernandez, J, Pichler W, Demoly P, Nizankowska-Mogilnicka, E., Hypersensitivity Database, Bonadonna, P., Brockow K, Torres MJ   +140 more
core   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Acute coronary syndrome in diclofenac sodium-induced type I hypersensitivity reaction : Kounis syndrome [PDF]

, 2007
Drug-induced type I hypersensitivity reactions are frequent. Sometimes, acute coronary syndrome (ACS) can be registered in such patients, which may have a serious impact on the course and management of the allergic reaction.
Panic, Milos, Putnikovic, Biljana, Jankovic-Gavrilovic, Jelena, Rasic-Milutinovic, Zorica, Gluvic, Zoran M., Stojkovic, Aleksandra   +5 more
core  

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Abacavir and the altered peptide repertoire model: Clinical implications [PDF]

, 2012
Structural and biochemical studies showing that abacavir binds non-covalently to the floor of the peptide binding groove of HLAB* 5701 with exquisite specificity to alter the self-peptides that load on the molecule to be presented to the immune system ...
Phillips, E., Mallal, S.
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