Results 41 to 50 of about 3,966,363 (347)

Drug hypersensitivity syndrome

Indian Journal of Dermatology, Venereology, and Leprology, 2011
Drug hypersensitivity syndrome (DHS) is an adverse drug reaction commonly associated with the aromatic antiepileptic drugs (AEDs), viz., phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), lamotrigine, primidone, etc. It can also be caused by other drugs, such as sulfonamides, dapsone, minocycline, gold derivatives, cyclosporine, captopril ...
Kumari, Rashmi, Timshina, Dependra K., Thappa, Devinder Mohan.   +2 more
openaire   +2 more sources

A Novel System to Diagnose Cutaneous Adverse Drug Reactions Employing the Cellscan—Comparison with Histamine Releasing Test and Inf-γ Releasing Test

Clinical and Developmental Immunology, 2005
Background: There are several mechanisms to describe allergic drug reactions yet the methods to diagnose them are limited.
Ilan Goldberg, Boris Gilburd, Martine Szyper Kravitz, Shmuel Kivity, Berta Ben Chaim, Tirza Klein, Yael Schiffenbauer, Ela Trubniykovr, Sarah Brenner, Yehuda Shoenfeld   +9 more
doaj   +1 more source

Biomarkers of immediate drug hypersensitivity

Allergy, 2023
AbstractImmediate drug hypersensitivity reactions (IDHRs) are a burden for patients and the health systems. This problem increases when taking into account that only a small proportion of patients initially labelled as allergic are finally confirmed after an allergological workup.
Cristobalina Mayorga, Adriana Ariza, Rosa Muñoz‐Cano, Vito Sabato, Inmaculada Doña, Maria J. Torres   +5 more
openaire   +5 more sources

EAACI position paper on how to classify cutaneous manifestations of drug hypersensitivity

Allergy. European Journal of Allergy and Clinical Immunology, 2018
Drug hypersensitivity reactions (DHRs) are common, and the skin is by far the most frequently involved organ with a broad spectrum of reaction types. The diagnosis of cutaneous DHRs (CDHR) may be difficult because of multiple differential diagnoses.
K. Brockow, M. Ardern-Jones, M. Mockenhaupt, W. Aberer, A. Barbaud, J. Caubet, R. Spiewak, M. Torres, C. Mortz   +8 more
semanticscholar   +1 more source

Clinical Characteristics and Disease Burden of Patients with Moderate-to-Severe Generalized Pustular Psoriasis Flares in Taiwan

Dermatology and Therapy
Introduction Generalized pustular psoriasis (GPP) is a rare and severe psoriasis subtype characterized by the rapid onset of coalescing sterile pustules over broad body areas and systemic inflammation.
Chun-Wei Lu, Chien-Yu Tseng, Chuang-Wei Wang, Shang-Hung Lin, Chun-Bing Chen, Rosaline Chung-Yee Hui, Ching-Chi Chi, Yu-Huei Huang, Chih-Hung Lee, Fang-Ju Lin, Wen-Hung Chung   +10 more
doaj   +1 more source

The Mechanism of Onychomadesis (Nail Shedding) and Beau’s Lines Following Hand-Foot-Mouth Disease

Viruses, 2019
Background: Nail changes, including onychomadesis (nail shedding) and Beau’s line, following hand-foot-mouth disease (HFMD) are a common emergence at the stage of late complications of HFMD. However, the exact mechanism is still unknown. Therefore,
Hsiu-Hui Chiu, Ming-Tsan Liu, Wen-Hung Chung, Yu-Shien Ko, Chin-Fang Lu, Cheng-Che E. Lan, Chun-Wei Lu, Kai-Che Wei   +7 more
doaj   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source

Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade

Nature Communications
Immune checkpoint inhibitors (ICI) represent new anticancer agents and have been used worldwide. However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epidermal necrolysis ...
Chun-Bing Chen, Shuen-Iu Hung, John Wen-Cheng Chang, Chan-Keng Yang, David Hui-Kang Ma, Yu-Chuan Teng, Chun-Wei Lu, Wei-Ti Chen, Hsiao-Yin Yang, Cheng-Chang Tsai, Chih Liang Wang, Pin-Hsuan Chiang, Jennifer Wu, Ya-Wen Tsai, Lai-Ying Lu, Yang Yu-Wei Lin, Rosaline Chung-Yee Hui, Fu-Mei Hsieh, Chao-Kai Hsu, Chaw-Ning Lee, Yi-Ju Chen, Chih-Chiang Chen, Yilei Cui, Hung-Chih Hsu, Ya-Ching Chang, Chih-Jung Chang, Ho-Chen Lin, Chee Jen Chang, Yu-Jr Lin, Cheng-Lung Ku, Chuang-Wei Wang, Wen-Hung Chung   +31 more
doaj   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Pharmacogenetics of hypersensitivity drug reactions [PDF]

Therapies, 2017
Adverse drug reactions are a significant cause of morbidity and mortality and represent a major burden on the healthcare system. Some of those reactions are immunologically mediated (hypersensitivity reactions) and can be clinically subdivided into two categories: immediate reactions (IgE-related) and delayed reactions (T-cell-mediated).
NEGRINI, SIMONE, Becquemont, Laurent
openaire   +5 more sources