Results 71 to 80 of about 3,966,363 (347)

Artificial Intelligence‐Driven Nanoarchitectonics for Smart Targeted Drug Delivery

Advanced Materials, EarlyView.
This perspective introduces an artificial intelligence (AI)‐driven nanoarchitectonics framework for targeted drug delivery, combining database‐guided nanocarrier design, machine learning (ML)‐assisted surface engineering with a designed targeting system, and in silico modeling for dynamic optimization.
Hayeon Bae, Hyunsub Ji, Konstantin Konstantinov, Ronald Sluyter, Katsuhiko Ariga, Yong Ho Kim, Jung Ho Kim   +6 more
wiley   +1 more source

The role of drug, dose, and the tolerance/intolerance of new drugs in multiple drug hypersensitivity syndrome

Allergy. European Journal of Allergy and Clinical Immunology, 2019
Multiple drug hypersensitivity syndrome (MDH) is used to describe persons with a drug hypersensitivity reaction (DHR) to at least two chemically unrelated drugs, confirmed by skin test or in vitro assay.
Lukas Jörg, Daniel Yerly, A. Helbling, W. Pichler   +3 more
semanticscholar   +1 more source

Genotyping for Severe Drug Hypersensitivity [PDF]

Current Allergy and Asthma Reports, 2014
Over the past decade, there have been significant advances in our understanding of the immunopathogenesis and pharmacogenomics of severe immunologically-mediated adverse drug reactions. Such T-cell-mediated adverse drug reactions such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug-induced liver disease (DILI) and other drug ...
Elizabeth J. Phillips, Elizabeth J. Phillips, Eric Karlin   +2 more
openaire   +3 more sources

Autonomous Implants

Advanced Materials, EarlyView.
An ideal implant should mimic native tissues such that it can integrate, sense, heal, and continue to function, i.e., be autonomous. Although early, there are good steps taken in this way, e.g., the development of stimuli‐responsive, self‐powering, self‐actuating, self‐healing, self‐regenerating, and self‐aware implants.
Jagan Mohan Dodda, Marcel F. Kunrath, Ling Zhou Zhao, Mahdi Bodaghi, Armin Yousefi, Nureddin Ashammakhi   +5 more
wiley   +1 more source

Fixed drug eruption and anaphylaxis induced concurrently by erdosteine: a case report

Allergy, Asthma & Clinical Immunology, 2021
Background Erdosteine is used as a mucolytic agent and has a low incidence of adverse drug reactions, most of which are gastrointestinal and mild. Moreover, drug antigens rarely induce multiple simultaneous immunologic reactions.
Da Woon Sim, Ji Eun Yu, Young-Il Koh
doaj   +1 more source

Multifunctional Bioactive Coatings Based on Bioglass, Vitamin D3, and Melittin Deposited via MAPLE for Enhanced Osseointegration, Antibacterial Activity, and Corrosion Resistance of Titanium Implants

Advanced Materials Interfaces, EarlyView.
Matrix‐Assisted Pulsed Laser Evaporation (MAPLE) technique is used to cover titanium (Ti) substrates with multifunctional bioactive coatings composed of bioglass, vitamin D3, and melittin. Coatings exhibited excellent chemical integrity and favorable micro/nanostructured morphology (promoting cellular adhesion and viability), and a sustained release of
Irina Negut, Bogdan Bita, Mihaela Dinu, Anca Constantina Parau, Tatiana Tozar, Oana Gherasim, Valentina Grumezescu, Carmen Ristoscu, Luminita Marutescu, Gratiela Gradisteanu Pircalabioru   +9 more
wiley   +1 more source

The Time Delay Between Drug Intake and Bronchospasm for Nonsteroidal Antiinflammatory Drugs Sensitive Patients

World Allergy Organization Journal, 2010
A study was performed to assess the time between drug intake and drug induced hypersensitivity reaction for patients sensitive to nonsteroidal antiinflammatory drugs (NSAID) in clinical patient history and after oral provocation tests.
Giedre Grigiene, MD, Jolita Norkūnienė, PhD, Violeta Kvedariene, MD, PhD   +2 more
doaj   +1 more source

Analysis of the Costs Associated With the Elective Evaluation of Patients Labelled as Allergic to Beta-Lactams or Nonsteroidal Antiinflamatory Agents

Frontiers in Pharmacology, 2020
Introduction: Being labelled as allergic to different drugs results in patients receiving other treatments, which are more toxic, less effective and more expensive.
Miriam Sobrino-García, Esther M. Moreno, Esther M. Moreno, Esther M. Moreno, Esther M. Moreno, Francisco J. Muñoz-Bellido, Francisco J. Muñoz-Bellido, Francisco J. Muñoz-Bellido, Maria T. Gracia-Bara, Maria T. Gracia-Bara, Elena Laffond, Elena Laffond, Elena Laffond, Inmaculada Doña, Inmaculada Doña, Inmaculada Doña, Cristina Martín, Cristina Martín, Eva M. Macías, Eva M. Macías, Eva M. Macías, Sonia de Arriba, Sonia de Arriba, Sonia de Arriba, Valle Campanón, Alicia Gallardo, Ignacio Dávila, Ignacio Dávila, Ignacio Dávila, Ignacio Dávila   +29 more
doaj   +1 more source

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Advanced Science, EarlyView.
J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu, Jia‐Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng‐Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng‐Lin Lu, Chuanjun Tong, Ed X. Wu, Qiu‐gen Hu, Xiong Cao, Yanqiu Feng   +15 more
wiley   +1 more source

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

Clinical and Translational Allergy, 2018
s from the 8th Drug Hypersensitivity Meeting (DHM) Amsterdam, the Netherlands. 19-21 April 2018 Published: 21 August 2018 © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ...
M. Bakhtiar, C. Too, M. Tang, L. Kim, Tan, S. Sulaiman, N. A. A. Fauzi, Anastasia Ria Nagum, P. Illing, J. Farrell, Mohammad, Alhaidari, N. Berry, P. O’Neill, A. Purcell, K. Urbancic, S. Khumra, Steven T Walker, A. Douglas, O. Smibert, A. Aung, E. Phillips, Jason, A. Trubiano   +23 more
semanticscholar   +1 more source