Results 91 to 100 of about 938,469 (359)

Optimization of Protein-Protein Interaction Measurements for Drug Discovery Using AFM Force Spectroscopy [PDF]

, 2019
Increasingly targeted in drug discovery, protein-protein interactions challenge current high throughput screening technologies in the pharmaceutical industry.
Basson, Marc D., Chen, Liangliang, Dong, Lixin, Hou, Jing, Jiao, Nian-Dong, Liu, Lianqing, Monemianesfahani, Amir, Sun, Zhiyong, Xi, Ning, Yang, Ruiguo, Yang, Yongliang, Zeng, Bixi   +11 more
core   +1 more source

Liaisons Dangereuses? new drugs, physicians and the drug industry. [PDF]

Bone Marrow Transplant, 2021
Gale RP, Lazarus HM.
europepmc   +1 more source

Requirement of collaboration between pharmacologists and pathologists for drug discovery research: From a viewpoint of the pharmaceutical industry

, 2022
Motowo Nakajima
openalex   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The Determinants of Pharmaceutical R&D Expenditures: Evidence from Japan [PDF]

During the past 20 years, the world pharmaceutical industry has experienced a dramatic increase in R&D intensity. We apply and extend a model developed by Grabowski and Vernon (2000) with a pooled data sample of the 15 publicly listed Japanese drug firms
Mahlich, Jörg C., Roediger-Schluga, Thomas   +1 more
core  

Alcohol and other drugs in the Australian construction industry: a pathway for safety focused cultural change [PDF]

, 2013
Background: Anecdotal evidence from the infrastructure and building sectors highlights issues of alcohol and other drugs (AODs) and its association with safety risk on construction sites.
Biggs, Herbert, Williamson, Amy
core   +1 more source

Articulação da indústria farmacêutica brasileira com o exterior: há evidências de especialização regressiva?

Cadernos de Saúde Pública
Em caráter exploratório, o objetivo deste artigo é investigar se há indícios de especialização regressiva no padrão de comércio exterior da indústria farmacêutica brasileira, a partir da liberalização comercial dos anos 1990.
Fábio Batista Mota, José Eduardo Cassiolato, Carlos Augusto Grabois Gadelha   +2 more
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Drug Abuse in the Hospitality Industry [PDF]

, 1993
Drug and alcohol abuse in the hospitality industry is an ongoing problem, reflective of business as a whole. A series of surveys were conducted at national drug rehabilitation centers seeking information from patients currently or formerly employed in ...
Eade, Vincent H.
core  

A novel and practical asymmetric synthesis of eptazocine hydrobromide

Beilstein Journal of Organic Chemistry, 2018
In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of N-(p-trifluoromethylbenzyl)cinchonidinium bromide.
Ruipeng Li, Zhenren Liu, Liang Chen, Jing Pan, Kuaile Lin, Weicheng Zhou   +5 more
doaj   +1 more source