Results 11 to 20 of about 285,764 (313)

Preparation and Study on the Single-Crystal Structure of Flurbiprofen–Salicylamide Co-crystal

open access: yesPharmaceutical Fronts, 2023
Co-crystals can improve the physicochemical properties of pharmaceutical active ingredients, and thus have great potential in improving drug performance.
Jia-Wei Hou   +6 more
doaj   +1 more source

Teaching medical students how to interact with the pharmaceutical industry: A scoping review

open access: yesGMS Journal for Medical Education, 2022
Objectives: The influence of the pharmaceutical industry is of significant concern in physician prescribing decisions; medical students may not be fully equipped with the knowledge or skills to manage interactions with industry prior to graduation.
Farah, Samiyah, Bilszta, Justin L.
doaj   +1 more source

Drugs, Industry, and Academia [PDF]

open access: yesScience, 2008
This week, international academic and industry leaders, investors, and policy-makers participated in the Biotechnology Industry Organization9s International Convention in San Diego, a reminder that prospects for new drugs seem bleak. Only 17 new molecular entities were approved by the U.S.
openaire   +2 more sources

Anticoccidial drugs of the livestock industry [PDF]

open access: yesParasitology Research, 2019
Coccidiosis is a parasitic disease of a wide variety of animals caused by coccidian protozoa. The coccidia are responsible for major economic losses of the livestock industry. For example, the annual cost due to coccidiosis to the global poultry industry has been estimated to exceed US$ 3 billion annually.
Sandra Noack   +2 more
openaire   +2 more sources

Physician-industry relationship and conflicts of interest: Historical, normative aspects, negative impact and proposals

open access: yesIatreia, 2019
This article presents a narrative review of the relationship between physicians and industry (RPI), which includes pharmaceutical, devices and supplements’ industries and the conflicts of interest that arise from this relationship.
Genta Mesa, Giuseppe   +1 more
doaj   +1 more source

Improvement of Nemadectin Production by Overexpressing the Regulatory Gene nemR and Nemadectin Biosynthetic Gene Cluster in Streptomyces Cyaneogriseus

open access: yesPharmaceutical Fronts, 2020
Nemadectin, a 16-member macrocyclic lactone antiparasitic antibiotic, is produced by Streptomyces cyaneogriseus subspecies noncyanogenus. Moxidectin, a C-23 oximate derivative of nemadectin, is widely used as a pesticide due to its broad-spectrum, highly
Yuan-Jie Wu   +3 more
doaj   +1 more source

Structural Characterization of Chemical Compounds Based on Their Fragmentation Rules in Sophorae Fructus by UPLC-QTOF-MS/MS

open access: yesPharmaceutical Fronts, 2022
This study aims to identify the chemical components in Sophorae Fructus, and explore the mass spectrometric cleavage rules using the UPLC-Q-TOF-MS/MS method. The main characteristic fragments of the compounds were analyzed by electrospray ionization (ESI)
Zi-Hui He   +3 more
doaj   +1 more source

Extending the in vivo Half-Life of Adalimumab Fab via Sortase A-Mediated Conjugation of Adalimumab Fab with Modified Fatty Acids

open access: yesPharmaceutical Fronts, 2020
Adalimumab, a full-length monoclonal antibody, is widely used as an anti-tumor necrosis factor-α (anti-TNF-α) agent. In this article, we aimed to prolong the in vivo half-life of adalimumab antigen-binding fragment (Fab) through Sortase A (SrtA)-mediated
Qing-Bin Zhang   +5 more
doaj   +1 more source

Recent Research Advances in Small-Molecule Pan-PIM Inhibitors

open access: yesPharmaceutical Fronts, 2022
PIM kinase is consequently emerging as a promising target for cancer therapeutics and immunomodulation. PIM kinases are overexpressed in a variety of hematological malignancies and solid tumors, and their inhibition has become a strong therapeutic ...
Lei Xu   +5 more
doaj   +1 more source

Enantioselective aza-Michael Cyclization Reaction Catalyzed by Quinine-Derived Monoquaternary Ammonium Salts: an Effective Route to Synthesize Letermovir

open access: yesPharmaceutical Fronts, 2021
A series of mono- or bis-quaternary ammonium salts derived from cinchonidine or quinine was synthesized and screened as potent phase-transfer catalysts for the reaction of aza-Michael cyclization, the key step in the synthesis of letermovir.
Liang Chen   +7 more
doaj   +1 more source

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