Results 41 to 50 of about 5,201,027 (314)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluation Of The Performance Of Companies Operating In The Pharmaceutical Sector For Reverse Logistics Applications With TOPSIS and MOORA Methods

Journal of Transportation and Logistics, 2019
Reverse logistics activities, which are the process of taking products back to the supply chain point for disposal and recycling are quite expensive and complex.
Batuhan Kocaoğlu, Aykut Küçük
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Marketing research of the national antiarrhythmic drugs market

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
The purpose – marketing research of the national antiarrhythmic drugs market.Materials and methods. The State Register of Medicinal Products of Ukraine and Compendium-2019 were used as the research materials. Methods of system, marketing, statistical and
T. P. Zarichna, T. S. Raikova, T. S. Brytanova, Assani Doshi Rainna   +3 more
doaj   +1 more source

The Role of Oral Controlled Release Matrix Tablets in Drug Delivery Systems [PDF]

, 2012
Formulations that are able to control the release of drug have become an integral part of the pharmaceutical industry. In particular oral drug delivery has been the focus of pharmaceutical research for many years.
Raja, Shaista, Ali Nokhodchi, Shaista Raja, Pryia Patel, Asare-Addo, Kofi, Patel, Pryia, Kofi Asare-Addo, Shaista Raja (16203524), Nokhodchi, Ali, Priya Patel (679595), Ali Nokhodchi (4465915), Kofi Asare-Addo (4172488)   +11 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Farmacologia no século XX: a ciência dos medicamentos a partir da análise do livro de Goodman e Gilman Pharmacology in the twentieth century: the science of drugs through the analysis of Goodman and Gilman's textbook

História, Ciências, Saúde: Manguinhos, 2013
Analisa a apresentação da farmacologia como ciência a partir do livro-texto de Louis Goodman e Alfred Gilman reeditado e reimpresso inúmeras vezes entre 1941 e 2006. Nas primeiras edições, a farmacologia é caracterizada
Silvia Cardoso Bittencourt, Sandra Caponi, Sônia Maluf   +2 more
doaj  

A new era for African health systems: Market shaping and the African Continental Free Trade Area (AfCFTA)

Public Health Challenges
The COVID‐19 pandemic has forced a reflection on the origins of supplies in African healthcare market and underscored the need for an increase in local manufacturing of medical supplies. Several African countries’ health markets have been heavily reliant
Jonta Kamara, Ukeme Essien, Alain Labrique   +2 more
doaj   +1 more source

Evaluation of Biological Mechanisms of Quanduzhong Capsule for Treating Osteoporosis by Integrating Untargeted Metabolomics and Network Pharmacology

Pharmaceutical Fronts, 2023
Osteoporosis (OP) is a metabolic disease characterized by bone formation and resorption disturbances. Quanduzhong Capsule (QDZC) is a common treatment for OP in China; however, the effective components and metabolites of the drug after oral ...
Fang-Fang Yu, Le-Yi Huang, Man-Man Li, Shi-Wen Cui, Jie Yuan, Xiao-Feng Li, Tong Wu   +6 more
doaj   +1 more source

Western Hemisphere Drug Policy Commission [website]

, 2021
Website of the Western Hemisphere Drug Policy Commission (WHDPC), charged to "evaluate a range of US counternarcotics programs in the Americas and then make recommendations to improve them" -- including a recording and transcript of the group's hearing ...
United States. Western Hemisphere Drug Policy Commission.
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