Results 131 to 140 of about 11,447,845 (407)

Potensi Interaksi Obat Pada Pasien Gangguan Ginjal Kronis di Instalasi Rawat Inap RSUD Dr. Moewardi Tahun 2014 [PDF]

open access: yes, 2016
Chronic kidney disease (CKD) is a condition which characterized by a gradual loss of kidney function accompanied by manifestations of kidney pathology abnormality for at least three months. Patients with chronic kidney disease who have some complications
Khasanah, Rizqi Nurul
core  

Systematic discovery of drug interaction mechanisms

open access: yesMolecular Systems Biology, 2015
Drug combinations are increasingly important in disease treatments, for combating drug resistance, and for elucidating fundamental relationships in cell physiology.
G. Chevereau, T. Bollenbach
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Optimization of Protein-Protein Interaction Measurements for Drug Discovery Using AFM Force Spectroscopy [PDF]

open access: yes, 2019
Increasingly targeted in drug discovery, protein-protein interactions challenge current high throughput screening technologies in the pharmaceutical industry.
Basson, Marc D.   +11 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

DDIGIP: predicting drug-drug interactions based on Gaussian interaction profile kernels

open access: yesBMC Bioinformatics, 2019
Background A drug-drug interaction (DDI) is defined as a drug effect modified by another drug, which is very common in treating complex diseases such as cancer.
Cheng Yan   +4 more
doaj   +1 more source

Trends of Analytical Research on Drug-drug Interaction [PDF]

open access: yes, 2014
薬物-薬物相互作用は薬物治療において非常に重要な事項である。薬物はそれ自身で副作用を生じうるが、複数の薬物を併用することで予期しない重篤な有害事象を引き起こすこともある。この意味で、薬物-薬物相互作用に関する分析化学的な研究が非常に重要であり、薬物治療の手助けとなる。本総説では、薬物-薬物相互作用の分析化学的研究の最近の動向について、特に微小透析技術に基づいた方法について記述する。Drug-drug interaction is very important matter for the ...
Kenichiro NAKASHIMA   +7 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Evaluation of RNA Secondary Stem-Loop Structures in the UTRs of Mouse Hepatitis Virus as New Therapeutic Targets

open access: yesPathogens
MHV-A59 is a beta-coronavirus that causes demyelinating encephalitis and hepatitis in mice. Recently, the mouse infection model of MHV-A59 has been used as an alternative animal infection model for SARS-CoV and SARS-CoV-2, aiding the development of new ...
Gyuhyun Kang   +5 more
doaj   +1 more source

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