Results 141 to 150 of about 1,220,078 (316)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Physicians’ awareness and use of drug-drug interactions software: A preliminary study
Ibom Medical JournalBackground: Drug-drug interactions software is used as a tool to investigate clinically harmful interactions. Prescribers need to be aware of these tools to improve the quality of drug prescriptions, thus ensuring better patient care.
Oriaifo OG, Opadeyi AO, Isah AO
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2017 Yuping Wei,1 Liang Ma,2 Liang Zhang,1,2 Xia Xu2 1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 2School of Chemistry and Chemical Engineering, Anhui University of Technology ...
Ma L, Wei YP, Zhang L, Xu X
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
The impact of marketised discourse on the interaction between drug representatives and physicians [PDF]
, 2010 Drug representatives (‘drug reps’) visit physicians to present and promote pharmaceutical products (‘drug detailing’). Against the background of a continuous innovative slow-down, drug companies have shifted strategic emphasis towards marketing and ...
GEHRKE, JOST-TILO,ALEXANDER
core
An ontology for drug-drug interactions [PDF]
, 2014 Drug-drug interactions form a significant risk group for adverse effects associ-ated with pharmaceutical treatment. These interactions are often reported in the literature, however, they are sparsely represented in machine-readable re-sources, such as online databases, thesauri or ontologies.
María Herrero-Zazo +5 more
openaire +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source