Results 161 to 170 of about 1,087,510 (314)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A comparison of five different drug-drug interaction checkers for selective serotonin reuptake inhibitors. [PDF]

Front Pharmacol
Xu S, Song Z, Li Y, Bai J, Wang D, Wang E, Wang J.   +6 more
europepmc   +1 more source

Interaction of Diazepam with the Muscle-relaxant Drugs [PDF]

, 1970
S. A. Feldman, Barbara Crawley
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Vascularized Tumor-on-a-Chip Model as a Platform for Studying Tumor-Microenvironment-Drug Interaction. [PDF]

Macromol Biosci
Kim H, Cho SW, Kim HN.
europepmc   +1 more source

Interaction of benzodiazepine drugs with striatal dopaminergic neurons in the brain

, 1976
Kazuo Nakamura, Keiji Nakamura
openalex   +1 more source

The Interaction of d-Tubocurarine with Antiarrhythmic Drugs [PDF]

, 1970
Marvin D. Harrah, Walter L. Way, Bertram G. Katzung   +2 more
openalex   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

A comprehensive landscape of AI applications in broad-spectrum drug interaction prediction: a systematic review. [PDF]

J Cheminform
Marzouk NH, Selim S, Elattar M, Mabrouk MS, Mysara M.   +4 more
europepmc   +1 more source

Interaction of Drugs, Steroids and Fatty Acids with Liver-Microsomal Cytochrome P-450 [PDF]

, 1970
David Kupfer, Sten Orrenius
openalex   +1 more source