Results 171 to 180 of about 6,287,371 (315)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Navigating uncertainty matters: Evaluating large language models for drug-drug interaction identification. [PDF]

J Manag Care Spec Pharm
Tilley A, Murray B, Henry K, Zhao X, Gao Y, Blotske K, Sikora A.   +6 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

DDI-HierPred: An Artificial Intelligence-Based Hierarchical PK/PD Platform for Drug-Drug Interaction Prediction. [PDF]

Pharmaceutics
Ouassaf M, Alhatlani BY.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Drug-Drug Interaction of Chiglitazar with Empagliflozin, Atorvastatin, and Valsartan: An Open-Label, Single-Center, Self-Control, 3-Period Study

Drug Design, Development and Therapy
Lei Sheng,1 Xuening Li,1 Jia Yu,2 Xiaodong Yang,2 Hui Li,1 Hongrong Xu1 1Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Department of Clinical Pharmacology, Shenzhen Chipscreen ...
Sheng L, Li X, Yu J, Yang X, Li H, Xu H
doaj  

Tail-aware heterogeneous graph neural networks for multi-class drug-drug interaction prediction. [PDF]

Bioinformatics
Venkatesh V, G V, S M D.
europepmc   +1 more source

Drug Interactions

Journal of the Royal College of Physicians of London, 1980
C T, Dollery, M J, Brodie
openaire   +2 more sources

An ontology for drug-drug interactions

, 2015
Drug-drug interactions form a significant risk group for adverse effects associ-ated with pharmaceutical treatment. These interactions are often reported in the literature, however, they are sparsely represented in machine-readable re-sources, such as online databases, thesauri or ontologies.
María Herrero-Zazo, Janna Hastings, Isabel Segura-Bedmar, Samuel Croset, Paloma Martínez, Christoph Steinbeck   +5 more
openaire   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source