Results 271 to 280 of about 11,447,845 (407)

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug-Drug Interaction Predictions. [PDF]

Clin Pharmacol Ther
Taskar KS, Sharma P, Rowland Yeo K.
europepmc   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Determination of food-drug interaction knowledge levels of pharmacists and senior pharmacy students. [PDF]

BMC Med Educ
Çakır A, Memi̇ş H.
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Adverse Drug-Drug Interaction Between Phenobarbital and Fluconazole in Two Dogs. [PDF]

J Vet Intern Med
Jaramillo M, Mondino A, Court M, Lewis MJ, Olby NJ, Muñana KR.   +5 more
europepmc   +1 more source

Breast Cancer Resistance Protein (ABCG2) in Clinical Pharmacokinetics and Drug Interactions: Practical Recommendations for Clinical Victim and Perpetrator Drug-Drug Interaction Study Design

Drug Metabolism And Disposition, 2015
Caroline A. Lee, M. O'Connor, Tasha K. Ritchie, A. Galetin, J. Cook, I. Ragueneau-Majlessi, H. Ellens, B. Feng, M. Taub, M. Paine, J. Polli, J. Ware, M. Zamek-Gliszczynski   +12 more
semanticscholar   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Spotting Trends in Side Effects and Drug Interactions: Data Visualization Tools Can Supplement Decision Making for Medical Prescribers

, 2018
J. A. Dodson
openalex   +2 more sources

Consensus Recommendations for Systematic Evaluation of Drug–Drug Interaction Evidence for Clinical Decision Support

Drug Safety, 2015
R. Scheife, L. Hines, R. Boyce, Sophie P Chung, J. Momper, Christine D. Sommer, Darrell R. Abernethy, J. Horn, S. J. Sklar, Samantha K. Wong, Gretchen Jones, Mary Brown, A. Grizzle, Susan Comes, T. L. Wilkins, Clarissa Borst, Michael A. Wittie, D. Malone   +17 more
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source