Results 1 to 10 of about 1,942,106 (197)

Pharmacokinetic Drug–Drug Interactions and Herb–Drug Interactions [PDF]

Pharmaceutics, 2021
Due to the growing use of herbal supplementation—ease of taking herbal supplements with therapeutics drugs (i [...]
Min-Koo Choi, Im-Sook Song
doaj   +3 more sources

Predicting drug-target interactions using drug-drug interactions. [PDF]

PLoS ONE, 2013
Computational methods for predicting drug-target interactions have become important in drug research because they can help to reduce the time, cost, and failure rates for developing new drugs.
Shinhyuk Kim, Daeyong Jin, Hyunju Lee
doaj   +5 more sources

Navigating Drug–Drug Interactions in Clinical Drug Development: A Tutorial [PDF]

Clinical and Translational Science
This tutorial provides essential guidelines and insights, in addition to regulatory guidance, for the evaluation of drug–drug interactions (DDIs), with a focus on the tools and timing of assessment critical for effective management of inclusion/exclusion
Jesmin Lohy Das, Antoinette (Toni) Ajavon‐Hartmann, Virginia (Ginny) D. Schmith   +2 more
doaj   +2 more sources

Food-Drug Interactions

Oman Medical Journal, 2011
The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction), food, beverages, dietary supplements the person is consuming (drug-nutrient/food interaction) or ...
Arshad Yar Khan, Nousheen Aslam, Rabia Bushra   +2 more
doaj   +3 more sources

Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding [PDF]

PeerJ, 2018
The structure-thermodynamics correlation analysis was performed for a series of fluorine- and chlorine-substituted benzenesulfonamide inhibitors binding to several human carbonic anhydrase (CA) isoforms.
Alexey Smirnov, Asta Zubrienė, Elena Manakova, Saulius Gražulis, Daumantas Matulis   +4 more
doaj   +2 more sources

Prevalence and Clinical Significance of Drug–Drug and Drug–Dietary Supplement Interactions among Patients Admitted for Cardiothoracic Surgery in Greece

Pharmaceutics, 2021
Background: Drug interactions represent a major issue in clinical settings, especially for critically ill patients such as those with cardiovascular disease (CVD) who require cardiothoracic surgery (CTS) and receive a high number of different medications.
Marios Spanakis, Maria Melissourgaki, George Lazopoulos, Athina E. Patelarou, Evridiki Patelarou   +4 more
doaj   +1 more source

Natural products in drug discovery: meeting the urgency for new antimicrobials for human and veterinary use

AIMS Molecular Science, 2023
The scenario of growing microbial resistance and of lack of interest of pharmaceutical companies in developing new antimicrobial drugs jeopardizes the present and the future of the treatment of infectious diseases.
Marcus Vinícius Dias-Souza, Arthur Azevedo Perpétuo, Gabriel Souza dos Santos, Luiz Felipe Carreiro Machado , Renan Martins dos Santos   +4 more
doaj   +1 more source

The Influence of Pharmacogenetics on the Clinical Relevance of Pharmacokinetic Drug–Drug Interactions: Drug–Gene, Drug–Gene–Gene and Drug–Drug–Gene Interactions

Pharmaceuticals, 2021
Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event.
Martina Hahn, Sibylle C. Roll
doaj   +1 more source

A network inference method for large-scale unsupervised identification of novel drug-drug interactions [PDF]

, 2013
Characterizing interactions between drugs is important to avoid potentially harmful combinations, to reduce off-target effects of treatments and to fight antibiotic resistant pathogens, among others.
Guimera, Roger, Sales-Pardo, Marta
core   +4 more sources

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources