Results 21 to 30 of about 10,950,669 (421)

Natural products in drug discovery: meeting the urgency for new antimicrobials for human and veterinary use

AIMS Molecular Science, 2023
The scenario of growing microbial resistance and of lack of interest of pharmaceutical companies in developing new antimicrobial drugs jeopardizes the present and the future of the treatment of infectious diseases.
Marcus Vinícius Dias-Souza, Arthur Azevedo Perpétuo, Gabriel Souza dos Santos, Luiz Felipe Carreiro Machado , Renan Martins dos Santos   +4 more
doaj   +1 more source

Drug–Drug Interactions with Direct Oral Anticoagulants

Clinical Pharmacokinetics, 2020
A large body of evidence suggests that not only direct anticoagulant effects but also major bleeding events and stroke prevention depend on plasma concentrations of direct oral anticoagulants (DOACs).
K. Foerster, S. Hermann, G. Mikus, W. Haefeli   +3 more
semanticscholar   +1 more source

The Influence of Pharmacogenetics on the Clinical Relevance of Pharmacokinetic Drug–Drug Interactions: Drug–Gene, Drug–Gene–Gene and Drug–Drug–Gene Interactions

Pharmaceuticals, 2021
Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event.
Martina Hahn, Sibylle C. Roll
doaj   +1 more source

A comprehensive evaluation of potentially significant drug-drug, drug-herb, and drug-food interactions among cancer patients receiving anticancer drugs

BMC Cancer, 2022
Introduction During the cancer treatment path, cancer patients use numerous drugs, including anticancer, supportive, and other prescribed medications, along with herbs and certain products.
Amer A. Koni, Maisa A. Nazzal, Bushra A. Suwan, Samah S. Sobuh, Najiya T. Abuhazeem, Asil N. Salman, Husam T. Salameh, Riad Amer, Sa’ed H. Zyoud   +8 more
doaj   +1 more source

COVID-19 Drug Interactions

, 2020
Elderly patients are at high risk of corona virus disease 2019 (COVID-2019) infection and severe COVID-19 patients are treated in intensive care units (ICU). Drug-drug interaction risk increased to 100% with eight or more medication use. Comorbidities in
Nursel Sürmelioğlu, K. Demirkan
semanticscholar   +1 more source

Drug-drug interactions of tacrolimus [PDF]

Hospital Pharmacology, 2015
Introduction: Tacrolimus, potent immunosupressive drug, has large inter- and intraindividual pharmacokinetic variability. The aim: The aim of this current topic is to describe the importance of tacrolimus drug-drug interactions.
Rančić Nemanja K., Vavić Neven N., Kovačević Aleksandra M., Mikov Momir M., Dragojević-Simić Viktorija M.   +4 more
doaj   +1 more source

Clinical Data on Canabinoids: Translational Research in the Treatment of Autism Spectrum Disorders

Biomedicines, 2022
Translational research made with Cannabis sativa L. and its biocompounds provides data for some targeted diseases, as also symptoms associated with Autism Spectrum Disorders (ASDs).
Laura D. Carreira, Francisca C. Matias, Maria G. Campos   +2 more
doaj   +1 more source

Medical Knowledge Graph QA for Drug-Drug Interaction Prediction based on Multi-hop Machine Reading Comprehension [PDF]

, 2022
Drug-drug interaction prediction is a crucial issue in molecular biology. Traditional methods of observing drug-drug interactions through medical experiments require significant resources and labor. This paper presents a medical knowledge graph question answering model, dubbed MedKGQA, that predicts drug-drug interaction by employing machine reading ...
arxiv   +1 more source

Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use

Journal of Clinical Medicine, 2019
Cannabidiol (CBD) is ubiquitous in state-based medical cannabis programs and consumer products for complementary health or recreational use. CBD has intrinsic pharmacologic effects and associated adverse drug events (ADEs) along with the potential for ...
Joshua D. Brown, A. Winterstein
semanticscholar   +1 more source

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit

Nature Communications, 2018
SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active in G1 ...
Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens, Renate König   +14 more
doaj   +1 more source