Results 71 to 80 of about 10,950,669 (421)

Principled Drug-Drug Interaction Terms for Bayesian Logistic Regression Models of Drug Safety in Oncology Phase I Combination Trials [PDF]

arXiv, 2023
In Oncology, trials evaluating drug combinations are becoming more common. While combination therapies bring the potential for greater efficacy, they also create unique challenges for ensuring drug safety. In Phase-I dose escalation trials of drug combinations, model-based approaches enable efficient use of information gathered, but the models need to ...
arxiv  

Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis

Science Advances, 2017
Geometrically optimized sampling of drug-dose combinations enables systematic identification of high-order drug synergies. Combinations of three or more drugs are used to treat many diseases, including tuberculosis.
Murat Cokol, Nurdan Kuru, Ece Bicak, Jonah Larkins-Ford, B. Aldridge   +4 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Associated factors of potential drug-drug interactions and drug–food interactions in patients with multiple sclerosis

Therapeutic Advances in Chronic Disease, 2022
Background: Multiple sclerosis (MS) is the most common immune-mediated demyelinating disease in younger adults. Patients with MS (PwMS) are vulnerable to the presence of potential drug–drug interactions (pDDIs) and potential drug–food interactions (pDFIs)
Jane Louisa Debus, Paula Bachmann, Niklas Frahm, Pegah Mashhadiakbar, Silvan Elias Langhorst, Barbara Streckenbach, Julia Baldt, Felicita Heidler, Michael Hecker, Uwe Klaus Zettl   +9 more
doaj   +1 more source

Predicting drug–drug interactions through drug structural similarities and interaction networks incorporating pharmacokinetics and pharmacodynamics knowledge

Journal of Cheminformatics, 2017
Drug–drug interactions (DDIs) may lead to adverse effects and potentially result in drug withdrawal from the market. Predicting DDIs during drug development would help reduce development costs and time by rigorous evaluation of drug candidates.
Takako Takeda, Ming Hao, Tiejun Cheng, S. Bryant, Yanli Wang   +4 more
semanticscholar   +1 more source

In silico identification of essential proteins in Corynebacterium pseudotuberculosis based on protein-protein interaction networks [PDF]

, 2016
Background Corynebacterium pseudotuberculosis (Cp) is a gram-positive bacterium that is classified into equi and ovis serovars. The serovar ovis is the etiological agent of caseous lymphadenitis, a chronic infection affecting sheep and goats, causing ...
Azevedo, Vasco, Barh, Debmalya, Ferreira, Rafaela Salgado, Folador, Edson Luiz, Ghosh, Preetam, Gromiha, Michael, Röttger, Richard, Sanches Daltro de Carvalho, Paulo Vinícius, Silva, Artur, Silva, Wanderson Marques   +9 more
core   +3 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Medication Appropriateness, Polypharmacy, and Drug-Drug Interactions in Ambulatory Elderly Patients with Cardiovascular Diseases at Tikur Anbessa Specialized Hospital, Ethiopia

Clinical Interventions in Aging, 2022
Limi Adem, Gobezie T Tegegne Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Science, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Gobezie T Tegegne, Email gobezie.temesgen@aau.edu.etBackground ...
Adem L, Tegegne GT
doaj  

Neutralization of cholera toxin by Rosaceae family plant extracts

BMC Complementary and Alternative Medicine, 2019
Background Cholera is one of the most deadly diarrheal diseases that require new treatments. We investigated the neutralization of cholera toxin by five plant extracts obtained from the Rosaceae family that have been traditionally used in Poland to treat
Magdalena Komiazyk, Malgorzata Palczewska, Izabela Sitkiewicz, Slawomir Pikula, Patrick Groves   +4 more
doaj   +1 more source

Novel Antiretroviral Therapeutic Strategies for HIV

Molecules, 2021
When the first cases of HIV infection appeared in the 1980s, AIDS was a deadly disease without any therapeutic alternatives. Currently, there is still no cure for most cases mainly due to the multiple tissues that act as a reservoir for this virus ...
Rita F. Cunha, Sandra Simões, Manuela Carvalheiro, José M. Azevedo Pereira, Quirina Costa, Andreia Ascenso   +5 more
doaj   +1 more source