Results 91 to 100 of about 1,107,910 (309)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Conformational analysis of fenoterol stereoisomers

Current Issues in Pharmacy and Medical Sciences
Fenoterol is a relatively long-acting selective agonist of β2 adrenergic receptor (β2-AR) used in the treatment of asthma. Its molecule contains two stereogenic centers, thus, the compound exists as four stereoisomers.
Anita Płazińska, Joanna Olek, Krzysztof Jóźwiak   +2 more
doaj  

Interactions médicamenteuses entre anti-inflammatoires non stéroïdiens et antihypertenseurs : approches pharmaco-épidémiologiques [PDF]

, 2013
Ce travail présente une approche conjointe de pharmacovigilance et de pharmaco-épidémiologie pour évaluer les interactions médicamenteuses (IM) entre Anti-Inflammatoires Non Stéroïdiens (AINS) et antihypertenseurs.
Fournier, Jean-Pascal
core  

Characterization of potential drug-drug interactions in patients hospitalized in the intensive care unit of a tertiary hospital in Bogotá [PDF]

, 2018
Introduction: Drug-drug interactions occur more frequently in intensive care units than in other services. However, in Colombia, there are few studies on this problem in critically ill patients.
Bustamante, Carlos, Hernández Londoño, Marcela, Carlos Bustamante, Tribiño, Gabriel, Bustamante Rojas, Carlos Eduardo, Hernández, Marcela, Gabriel Tribiño, Marcela Hernández   +7 more
core   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Drug interactions in epilepsy

Arquivos de Neuro-Psiquiatria, 1980
Interactions with antiepileptic drugs are common and may have important clinical consequences. The physician should always consider carefully the need for and the implications of adding a new drug to any therapeutic regime and should be prepared to think
Emilio Perucca
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Multimodal Nanobiophysical Profiling of Melanoma-Derived Small Extracellular Vesicles Reveals Glycan Signatures Associated with Tumor Progression

Nanotechnology, Science and Applications
Swamy Kasarla,1 Karolina Staniak,1,2 Magdalena Surman,3 Krystian Zajączkowski,1 Alicja Targońska,2 Grażyna Mosieniak,2 Konstancja Bobecka-Wesołowska,4 Josef Uskoba,5 Małgorzata Przybyło,3 ...
Kasarla S, Staniak K, Surman M, Zajączkowski K, Targońska A, Mosieniak G, Bobecka-Wesołowska K, Uskoba J, Przybyło M, Kobiela T   +9 more
doaj  

A STUDY ON POTENTIAL DRUG - DRUG INTERACTIONS IN MEDICINE DEPARTMENT OF A MULTI SPECIALTY TEACHING HOSPITAL [PDF]

, 2017
Aim of study: Drug-drug interaction (DDI) occurs when two or more drugs are simultaneously administered, where the effect of one drug is altered by the concomitant use of another drug.
Bhat, Tanmay, SHAREEF, JAVEDH, Menezes, Shannon Lianna   +2 more
core   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source