Results 91 to 100 of about 5,801,857 (300)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Clinical Interventions in Aging, 2022 Limi Adem, Gobezie T Tegegne Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Science, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Gobezie T Tegegne, Email gobezie.temesgen@aau.edu.etBackground ...
Adem L, Tegegne GT
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Journal of CheminformaticsIn drug development, managing interactions such as drug–drug, drug–disease, and drug–nutrient is critical for ensuring the safety and efficacy of pharmacological treatments.
Nour H. Marzouk +4 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Drug-drug interactions : from knowledge base to clinical impact
, 2014 Drug usage has increased steadily, and the more drugs used, the higher the risk for adverse effects or loss of effect due to drug-drug interactions. For drug prescribers it is difficult to know what drugs a patient is taking and whether they interact ...
Marine Andersson (18690100)
core +1 more source
The 1st DDIExtraction-2011 Challenge Task: Extraction of Drug-Drug Interactions from Biomedical Texts [PDF]
, 2011 Proceeding at: The 1st DDIExtraction-2011 Challenge Task: Extraction of Drug-Drug Interactions from Biomedical Texts. Took place September, 2011, in Huelva (Spain).We present an evaluation task designed to provide a framework for comparing different ...
Martínez Fernández, Paloma +2 more
core +3 more sources
Conformational analysis of fenoterol stereoisomers
Current Issues in Pharmacy and Medical SciencesFenoterol is a relatively long-acting selective agonist of β2 adrenergic receptor (β2-AR) used in the treatment of asthma. Its molecule contains two stereogenic centers, thus, the compound exists as four stereoisomers.
Anita Płazińska +2 more
doaj
Measuring drug similarity using drug–drug interactions
Quantitative BiologyCombination therapy is a promising approach to address the challenge of antimicrobial resistance, and computational models have been proposed for predicting drug–drug interactions.
Ji Lv +4 more
doaj +1 more source