Results 111 to 120 of about 5,558,618 (260)
Pharmacovigilance of Drug–Drug Interactions with Nirmatrelvir/Ritonavir
Infectious Diseases and TherapyIntroduction Nirmatrelvir/ritonavir (NMV/r) is approved in the United States (US) and more than 70 other countries for the treatment of mild to moderate COVID-19 in nonhospitalized adults at high risk for severe disease.
Victoria Hendrick +8 more
doaj +1 more source
AntibioticsDrug interactions are a significant and integral part of the concept of medication-related adverse events, whether referring to potential interactions or those currently observed in real-world conditions.
Andrei-Flavius Radu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Ohio BWC Drug-Free EZ Program : technical assistance manual : reference/resource guide
, 2002 Title from title screen (viewed Sept. 24, 2004).; "BWC-7648 (Rev. 7/18/2002)"--Screen 87 (i.e. p. 1 of form: Progress report, Drug-Free Workplace/Drug-Free EZ Program).; Electronic text (pdf, 89 p.).; Harvested from the web on 9/24 ...
Drug-Free EZ Program (Ohio. Bureau of Workers' Compensation)
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Drug-related problems with special emphasis on drug : drug interactions
, 2009 The aim of this thesis was to address some aspects of drug related problems with special regard to drug-drug interactions.In paper I we aimed to describe the scenario and frequency of drug-related problems (DRPs) in in-patients and to determine whether a
Buster Mannheimer (442516)
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Assessing the potential for drug interactions
, 2017 Understanding the potential for adverse drug reactions (ADRs), resulting from plant-drug interactions,is a key aspect of medicinal plant safety. The aim of this study was to provide an in-depth assessment of standardised extracts of Hyptis verticillata ...
Picking, D. +5 more
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Drug–Drug Interactions in Patients with Brucellosis: A Retrospective Analysis
Mediterranean Journal of Infection, Microbes and AntimicrobialsIntroduction: The prolonged duration of drug treatment and the need for combination therapy in brucellosis increase the risk of drug-related problems. One of the most significant drug-related problems is drug–drug interactions.
Bahar Çelebi +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source