Results 111 to 120 of about 5,801,857 (300)

Drug-nucleic acid interactions /

, 2001
This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.Includes ...
Chaires, Jonathan B.,editor., Waring, Michael J.,editor.   +1 more
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Exploratory Evaluation of Solanidine as an Endogenous Marker for CYP2D6‐Mediated Drug–Drug–Gene Interactions of Venlafaxine in Koreans

Clinical and Translational Science
CYP2D6‐mediated drug–drug–gene interactions (DDGIs) are known to influence the pharmacokinetics of venlafaxine and its metabolism to O‐desmethylvenlafaxine.
Sungyeun Bae, Ga‐Yeong Lee, Eunsol Yang, Woori Chae, Kyung‐Sang Yu, Joo‐Youn Cho, Anhye Kim, Namyi Gu, SeungHwan Lee   +8 more
doaj   +1 more source

Drug interactions with voriconazole

, 2015
Drug interactions are a potential problem with voriconazole therapy, due to the antifungal's extensive interaction with human cytochrome P450 enzymes and transporters.
VIALE, PIERLUIGI, LEWIS, RUSSEL EDWARD
core  

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Network-Based, Cross-Sectional Analysis of Drug-Related Problems Reveals a Strong Association of Possible Inappropriate Medication and Clinical Outcomes in Romanian Elderly Nursing Home Residents

Medical Sciences
Background/Objectives: Polypharmacy is common in elderly nursing home residents (NHR), due to the high prevalence of chronic diseases. This practice increases the risk of clinically significant drug–drug interactions (DDIs) with serious consequences for ...
László-István Bába, Hanna Sebesi, Zsolt Gáll, Melinda Kolcsár, Soma Dávid, Noémi Eliza Medvés, George Jîtcă   +6 more
doaj   +1 more source

Drug-drug interactions with oral anticoagulants: information consistency assessment of three commonly used online drug interactions databases in Switzerland. [PDF]

Background: Toxicity or treatment failure related to drug-drug interactions (DDIs) are known to significantly affect morbidity and hospitalization rates.
Le Pogam, Marie-Annick, Le Pogam, M.A., Coumau, Claire, Gaspar, F., Terrier, Jean, Gaspar, Frederic, Csajka, C., Schulthess-Lisibach, Angela, Schulthess-Lisibach, A., Csajka, Chantal, Lutters, M., Coumau, C., Terrier, J., Lutters, Monika, Angela Schulthess-Lisibach, Chantal Csajka, Claire Coumau, Monika Lutters, Jean Terrier, Frederic Gaspar, Marie-Annick Le Pogam   +20 more
core   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source