Off-label use of cardiovascular drugs as an indicator of therapeutic need in paediatrics [PDF]
, 2023 Silvia Miriam Cammarata, Giacomo Capone
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Mining FDA drug labels using an unsupervised learning technique - topic modeling
BMC Bioinformatics, 2011 Background The Food and Drug Administration (FDA) approved drug labels contain a broad array of information, ranging from adverse drug reactions (ADRs) to drug efficacy, risk-benefit consideration, and more.
Xu Xiaowei +4 more
doaj +1 more source
A Comparison of Safety Information in Drug Labeling at the Initial Approval of New Drugs Approved Both in Japan and the United States. [PDF]
Ther Innov Regul Sci, 2022 Hoshino Y, Narukawa M.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Drug labeling changes and pediatric hematology/oncology prescribing: Measuring the impact of U.S. legislation. [PDF]
Clin Trials, 2021 Benning TJ +5 more
europepmc +1 more source
Extra-label drug use: with rights come responsibilities [PDF]
, 1996 Janis L. Cleland
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A multidisciplinary approach to verify and de-label of drug allergic histories in a university hospital in Thailand: a retrospective descriptive study [PDF]
, 2023 Sirinoot Palapinyo +4 more
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Supreme Court Amicus Brief Regarding Wyeth v. Diana Levine [PDF]
Prominent in arguments opposing preemption of state tort law liability for alleged inadequacies in prescription drug labeling is the argument that such liability can complement FDA regulation by improving on a regulatory scheme that fails to provide ...
Berndt, Ernst R. +5 more
core +1 more source