Results 81 to 90 of about 243,161 (291)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Is the Food and Drug Administration Safe and Effective? [PDF]
In the United States, drug safety and efficacy are primarily regulated by the Food and Drug Administration (FDA) and the legal system, which gives manufacturers large incentives to produce safe drugs and provide proper warnings for side effects, since ...
Eric Sun, Tomas J. Philipson
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Ultrafast and Selective Labeling of Endogenous Proteins Using Affinity-based Benzotriazole Chemistry
, 2022 Chemical modification of proteins is enormously useful for characterizing protein function in complex biological systems and for drug development. Selective labeling of native or endogenous proteins is challenging owing to the existence of distinct ...
Yuan, Zhou +7 more
core +1 more source
Pharmacovigilance in Action: Utilizing VigiBase Data to Improve Clozapine Safety
Patient Preference and AdherenceCarlos De las Cuevas,1 Emilio J Sanz,2,3 Jose de Leon4,5 1Department of Internal Medicine, Dermatology, and Psychiatry and Instituto Universitario de Neurociencia (IUNE), Universidad de La Laguna, La Laguna, Canary Islands, Spain; 2Department of Physical
De las Cuevas C, Sanz EJ, de Leon J
doaj
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Electronic Drug Labeling: No Consensus on the Advantages and Disadvantages of Its Exclusive Use [PDF]
, 2013 A letter report issued by the Government Accountability Office with an abstract that begins "GAO found no consensus among stakeholders on the advantages and disadvantages of eliminating paper labeling and relying instead on electronic labeling as a ...
United States. Government Accountability Office.
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Recent developments in heterocycle labeling with carbon isotopes
, 2018 International audienceHeterocycles play an essential role in modern pharmaceutical and agrochemical developments, representing a very common structural unit in marketed drugs.
Taran, Frédéric +7 more
core +1 more source
Communication of Survival Data in US Food and Drug Administration–Approved Labeling of Cancer Drugs
, 2021 This cross-sectional study examines how information on overall survival benefits of novel cancer drug indications is communicated in ...
Naci, Huseyin +4 more
core +1 more source