Results 71 to 80 of about 243,161 (291)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Should the United States Regulate Mandatory Labeling for Genetically Modified Foods? [PDF]

Public debate continues over whether the United States should regulate genetically modified (GM) foods by imposing a mandatory labeling policy. This paper develops a model that shows that a voluntary GM-labeling policy results in higher welfare than a ...
Huffman, Wallace, Tegene, Abebayehu, Rousu, Matthew, Shogren, Jason F.   +3 more
core  

Dataset for Desai et al. "Reporting of drug benefit in FDA-approved prescription drug labeling"

, 2019
All FDA labels and extraction sheets to support our paper, Desai et al. "Reporting of drug benefit in FDA-approved prescription drug labeling".
Desai, Bansri (6323888), Doshi, Peter (5297153), Desai, Bansri, Powers, John H., Hong, Kyungwan (5627150), Powers, John H. (6323891), Doshi, Peter, Hong, Kyungwan   +7 more
core   +1 more source

A general procedure for carbon isotope labeling of linear urea derivatives with carbon dioxide

, 2021
International audienceCarbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms.
Taran, Frédéric, Goudet, Amélie, Cahuzac, Héloïse, Loreau, Olivier, Sallustrau, Antoine, Caillé, Fabien, Audisio, Davide, del Vecchio, Antonio, Babin, Victor   +8 more
core   +1 more source

Identifying the most at-risk age-group and longitudinal trends of drug allergy labeling amongst 7.3 million individuals in Hong Kong

BMC Medicine
Background Incorrect drug ‘allergy’ labels remain a global public health concern. Identifying regional trends of drug allergy labeling can guide appropriate public health interventions, but longitudinal or population drug allergy studies remain scarce ...
Valerie Chiang, Andy Ka Chun Kan, Chinmoy Saha, Elaine Y. L. Au, Philip H. Li   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Table1_BERT-Based Natural Language Processing of Drug Labeling Documents: A Case Study for Classifying Drug-Induced Liver Injury Risk.DOCX

, 2021
Background & Aims: The United States Food and Drug Administration (FDA) regulates a broad range of consumer products, which account for about 25% of the United States market.
Yue Wu (1262184), Minjun Chen (320158), Zhichao Liu (191718), Weida Tong (15158), Leihong Wu (186700)   +4 more
core   +1 more source

Zolpidem prescribing practices before and after Food and Drug Administration required product labeling changes

SAGE Open Medicine, 2017
Background: Women have higher morning serum zolpidem concentrations than men after taking an evening dose, potentially leading to increased risk of harm.
Jessica L Norman, Danielle R Fixen, Joseph J Saseen, Laura M Saba, Sunny A Linnebur   +4 more
doaj   +1 more source

Label-free drug discovery [PDF]

Frontiers in Pharmacology, 2014
Current drug discovery is dominated by label-dependent molecular approaches, which screen drugs in the context of a predefined and target-based hypothesis in vitro. Given that target-based discovery has not transformed the industry, phenotypic screen that identifies drugs based on a specific phenotype of cells, tissues, or animals has gained renewed ...
openaire   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source