Results 51 to 60 of about 2,328,071 (294)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Dataset for Desai et al. "Reporting of drug benefit in FDA-approved prescription drug labeling"

, 2019
All FDA labels and extraction sheets to support our paper, Desai et al. "Reporting of drug benefit in FDA-approved prescription drug labeling".
Desai, Bansri (6323888), Doshi, Peter (5297153), Desai, Bansri, Powers, John H., Hong, Kyungwan (5627150), Powers, John H. (6323891), Doshi, Peter, Hong, Kyungwan   +7 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Super Fibonacci Graceful Labeling of Some Special Class of Graphs [PDF]

, 2011
A Fibonacci graceful labeling and a super Fibonacci graceful labeling on graphs were introduced by Kathiresan and Amutha in ...
Sridevi, R., Navaneethakrishnan, S., Nagarajan, K.   +2 more
core   +1 more source

Packaging and Labeling of Pharmaceutical Products Obtained from the Internet

Journal of Medical Internet Research, 2011
BackgroundFor patients, the prescription container label may be the only source of instructions on how to take their medicines. In the United States, the legal requirements for a prescription label are set by federal law and state statutes. The container
Veronin, Michael
doaj   +1 more source

Patient-reported outcomes labeling for oncology drugs: Multidisciplinary perspectives on current status and future directions

Frontiers in Pharmacology, 2022
Introduction: Regulatory agencies encourage the incorporation of the patient voices throughout clinical drug development. Patient-Reported Outcomes (PROs) offer one way of doing this and their use has markedly increased in many therapeutic areas ...
David Cella, Chieh-I Chen, Ruben G. W. Quek, Ainhoa Uribarren, Matthew Reaney, Vera Mastey, Deborah Collyar, Olivier Chassany, Olivier Chassany   +8 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Uso de medicamentos off-label e não licenciados em unidade de tratamento intensivo neonatal e sua associação com escores de gravidade Use of off-label and unlicensed drugs in the neonatal intensive care unit and its association with severity scores

Jornal de Pediatria, 2012
OBJETIVO: Avaliar a frequência da prescrição de medicamentos de uso não licenciado (UL) e off-label (OL) em recém-nascidos internados em unidade de tratamento intensivo neonatal de hospital de nível terciário e verificar a associação do seu uso com a ...
Clarissa G. Carvalho, Mariana R. Ribeiro, Mariana M. Bonilha, Mauro Fernandes Jr, Renato S. Procianoy, Rita C. Silveira   +5 more
doaj  

Association of Risk Perception and Information Provided on the Labels of Over-the-Counter Drugs: Role of Race, Education, Age and Income

Epidemiology, Biostatistics and Public Health, 2014
Background: The use of over-the-counter (OTC) drugs has increased tremendously, however, information on risk perception regarding the use of OTC drugs and their potential toxicity is scarce.
Sunil Mathur, Neha Singh, Katie Suda
doaj   +1 more source