Results 31 to 40 of about 244,106 (290)

An International Comparison of the Information in the Regulatory-Approved Drug Labeling and Prescribing Guidelines for Pediatric Depression [PDF]

, 2021
Objectives: To determine the differences in information between prescribing guidelines and drug labeling, as well as to compare the approval of psychotropic medicines for major depression in pediatric patients ("pediatric depression") across countries ...
Taylor, David, Nishtala, Prasad S, Latif, Asam, Tanana, Laila, Chen, Timothy F   +4 more
core   +1 more source

Tri-partite complex for axonal transport drug delivery achieves pharmacological effect. [PDF]

, 2010
BACKGROUND: Targeted delivery of pharmaceutical agents into selected populations of CNS (Central Nervous System) neurons is an extremely compelling goal.
Sokoloff Alan J, Miri D Rabinowitz, Munglani, Raj, Filler, Aaron G, Filler, A.G, Munglani, R, Chris Abell, Rabinowitz, Miri D, Terrence W Deacon, Andrew ML Lever, Deacon Terrence W, Munglani Raj, Mark Bacon, Sokoloff, Alan J, Franklyn A Howe, Deacon, T.W, Whiteside, Garth T, Bacon, Mark, Howe, F.A, Abell, Chris, Sokoloff, AJ, Griffiths, J.R, Filler Aaron G, Lever, Andrew ML, Howe, FA, Alan J Sokoloff, Martyn Frederickson, Bell B Anthony, Bell, B.A, Bacon, M, Frederickson Martyn, Garth T Whiteside, Griffiths, John R, Abell, C, Aaron G Filler, B Anthony Bell, Griffiths John R, Rabinowitz Miri D, Bacon Mark, Bell, B Anthony, Lever, A.M.L, Frederickson, Martyn, Filler, AG, Abell Chris, Sokoloff, A.J, Frederickson, M, John R Griffiths, Lever Andrew ML, Whiteside Garth T, Deacon, Terrence W, Bell, BA, Whiteside, GT, Griffiths, JR, Rabinowitz, MD, Deacon, TW, Lever, AM, Whiteside, G.T, Howe Franklyn A, Howe, Franklyn A, Raj Munglani, Rabinowitz, M.D   +60 more
core   +2 more sources

Carbon isotope labeling of carbamates by late-stage [$^{11}C$], [$^{13}C$] and [$^{14}C$] carbon dioxide incorporation [PDF]

, 2020
International audienceA general procedure for the late-stage[$^{11}C$], [$^{13}C$] and [$^{14}C$] carbon isotope labeling of cyclic carbamates is reported.
Taran, Frédéric, Destro, Gianluca, Talbot, Alex, Chevalier, Arnaud, Loreau, Olivier, Sallustrau, Antoine, Caillé, Fabien, Audisio, Davide, del Vecchio, Antonio   +8 more
core   +1 more source

Electroaffinity Labeling: A New Platform for Chemoproteomic-based Target Identification [PDF]

, 2022
Target identification is a critical pillar within the drug discovery process that involves deconvoluting the protein target of a pharmacologically active small molecule ligand.
Alexander, Sandahl, Olugbeminiyi, Fadeyi, Gary, Hermann, Yu, Kawamata, Aleksandra , Olow, phil, baran, Lee, Roberts, Eva, Rivera-Chao, Keun Ah , Ryu, Julien, Vantourout, La-Tonya, Adams, Rob , Oslund   +11 more
core   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Metabolic labeling of the bacterial peptidoglycan by functionalized glucosamine [PDF]

, 2022
N-Acetylglucosamine (GlcNAc) is an essential monosaccharide required in almost all organisms. Fluorescent labeling of the peptidoglycan (PG) on N-acetylglucosamine has been poorly explored.
Breukink, Eefjan, Cox, Ruud, Vollmer, Waldemar, Bao, Xue, Vos, Gaël, Xu, Yang, Lorent, Joseph H., Hernández-Rocamora, Víctor M., Wang, Xiaoqi, Stel, Marjon, Pieters, Roland J., Gray, Joe, van den Bos, Ramon M.   +12 more
core   +1 more source

GPCR structural characterization by NMR spectroscopy in solution

Acta Biochimica et Biophysica Sinica, 2022
In the human proteome, 826 G-protein-coupled receptors (GPCRs) interact with extracellular stimuli to initiate cascades of intracellular signaling. Determining conformational dynamics and intermolecular interactions are key to understand GPCR function as
Yang Lingyun, Liu Dongsheng, Wüthrich Kurt   +2 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Labeling of Immunobiological Drugs, Produced by the Russian Research An-ti-Plague Institution "Microbe" of the Rospotrebnadzor (Review)

Разработка и регистрация лекарственных средств, 2021
Introduction. This publication describes the design and implementation sequence of technological procedures for labeling immunobiological medicinal products produced by the FGHI RusRAPI "Microbe" of the Rospotrebnadzor.
A. V. Komissarov, O. A. Lobovikova, I. V. Shul'gina, V. S. Kostyuchenko, E. G. Abramova, O. A. Volokh, N. V. Sinitsyna, V. A. Demchenko, A. S. Fes'kova, A. K. Nikiforov   +9 more
doaj   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source