Results 41 to 50 of about 2,201,898 (294)

Isotopics – Isotopic labeling for Drug Innovation - H2020

, 2017
International audienceISOTOPICS (H2020 - Marie Sklodowska-Curie Actions - Innovative Training Network; grant number 675071) combines researchers and industry in an innovative effort to de-risk drug development, create new tools for medicine and train ...
Christophe Dugave, Hinsinger, Karen, Dugave, Christophe, Karen Hinsinger   +3 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Important missing information in Japan's risk management plans: a cross-sectional analysis after a decade of implementation

Frontiers in Medicine
IntroductionMore than 10 years have passed since Japan introduced risk management plans (RMPs), yet research focusing on important missing information (IMI) remains limited.
Natsuko Kameyama, Natsuko Kameyama, Ayana Ide, Hideki Maeda, Hideki Maeda   +4 more
doaj   +1 more source

Packaging and Labeling of Pharmaceutical Products Obtained from the Internet

Journal of Medical Internet Research, 2011
BackgroundFor patients, the prescription container label may be the only source of instructions on how to take their medicines. In the United States, the legal requirements for a prescription label are set by federal law and state statutes. The container
Veronin, Michael
doaj   +1 more source

Patient-reported outcomes labeling for oncology drugs: Multidisciplinary perspectives on current status and future directions

Frontiers in Pharmacology, 2022
Introduction: Regulatory agencies encourage the incorporation of the patient voices throughout clinical drug development. Patient-Reported Outcomes (PROs) offer one way of doing this and their use has markedly increased in many therapeutic areas ...
David Cella, Chieh-I Chen, Ruben G. W. Quek, Ainhoa Uribarren, Matthew Reaney, Vera Mastey, Deborah Collyar, Olivier Chassany, Olivier Chassany   +8 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Odd Harmonious Labeling of Some Graphs [PDF]

, 2012
The labeling of discrete structures is a potential area of research due to its wide range of applications.
Shah, N.H., Vaidya, S.K.
core   +1 more source

Level of Evidence Associated with FDA Safety Communications with Drug Labeling Changes: 2010-2014

INNOVATIONS in Pharmacy, 2017
Purpose: Approximately 800,000 safety reports are submitted to the FDA annually, however, only significant issues generate drug safety communications (DSC). The purpose of this study was to determine the type of clinical evidence used to warrant a change
Benjamin Hixon, Joseph M. Lowrey, Lindsay N Hume, Katelynn Mayberry, Maisha Kelly Freeman   +4 more
doaj   +1 more source

Fluorescence imaging of drug target proteins using chemical probes

Journal of Pharmaceutical Analysis, 2020
Fluorescence imaging can provide valuable information on the expression, distribution, and activity of drug target proteins. Chemical probes are useful small-molecule tools for fluorescence imaging with high structural flexibility and biocompatibility ...
Hao Zhu, Itaru Hamachi
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source