Enzyme-Based Labeling Strategies for Antibody–Drug Conjugates and Antibody Mimetics
Antibodies, 2018 Strategies for site-specific modification of proteins have increased in number, complexity, and specificity over the last years. Such modifications hold the promise to broaden the use of existing biopharmaceuticals or to tailor novel proteins for ...
Georg Falck, Kristian M. Müller
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Evaluation of color-coded drug labeling to identify endovenous medicines
Revista Brasileira de EnfermagemObjective: To analyze the opinion of nursing professionals on the design, practicality of use and the usefulness of color-coded drug labeling in a pediatric intensive care unit. Methods: A cross-sectional study with 42 nursing professionals.
Nayana Maria Gomes de Souza +4 more
doaj +1 more source
It Depends on What the Meaning of False is: Falsity and Misleadingness in Commercial Speech Doctrine [PDF]
, 2007 While scholarship regarding the Supreme Court\u27s noncommercial speech doctrine has often focused on the level of protection for truthful, non-misleading commercial speech, scholars have paid little attention to the exclusion of false or misleading ...
Tushnet, Rebecca
core +2 more sources
Outcomes of off-label drug uses in hospitals: a multicentric prospective study [PDF]
, 2014 Imma Danés +12 more
openalex +1 more source
A Review of Labeling Based on Patient-Reported Outcome Endpoints for New Oncology Drugs Approved by the European Medicines Agency (2017-2021) [PDF]
, 2023 Ari Gnanasakthy +4 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Research of ddi based on multi-label conditional random field
BIO Web of Conferences, 2017 The detection of drug name and drug-drug interaction(DDI) is considered as a sequence labeling task in this paper. We present the multi-label CRF method to complete it.
Yu Yangzhi, Deng Hongtao, Zhu Xun
doaj +1 more source
O-102 Analyses Of Current Unlicensed And Off-label For Age Drug Prescriptions At A Neonatal Intensive Care Unit: Abstract O-102 Table 1 [PDF]
, 2014 RB Flint +5 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source