Results 71 to 80 of about 471,442 (349)
Drug Recommendation toward Safe Polypharmacy [PDF]
arXiv, 2018 Adverse drug reactions (ADRs) induced from high-order drug-drug interactions (DDIs) due to polypharmacy represent a significant public health problem. In this paper, we formally formulate the to-avoid and safe (with respect to ADRs) drug recommendation problems when multiple drugs have been taken simultaneously.
arxiv
DTIAM: A unified framework for predicting drug-target interactions, binding affinities and activation/inhibition mechanisms [PDF]
arXiv, 2023 Accurate and robust prediction of drug-target interactions (DTIs) plays a vital role in drug discovery. Despite extensive efforts have been invested in predicting novel DTIs, existing approaches still suffer from insufficient labeled data and cold start problems.
arxiv
Save Now, Pay Later: The Unfortunate Reality of PLIVA v. Mensing [PDF]
, 2013 The article offers information related to the supreme courts decisions in PLIVA v. Mensing court case. It mentions that the court has ruled that generic drug companies cannot be sued under state law over allegations that they failed to provide adequate ...
Nehrbass, Fabian
core +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Frontiers in Pharmacology, 2020 Introduction: Being labelled as allergic to different drugs results in patients receiving other treatments, which are more toxic, less effective and more expensive.
Miriam Sobrino-García +29 more
doaj +1 more source
Modeling Drug-Disease Relations with Linguistic and Knowledge Graph Constraints [PDF]
arXiv, 2019 FDA drug labels are rich sources of information about drugs and drug-disease relations, but their complexity makes them challenging texts to analyze in isolation. To overcome this, we situate these labels in two health knowledge graphs: one built from precise structured information about drugs and diseases, and another built entirely from a database of
arxiv
Unveiling the Potential of Knowledge-Prompted ChatGPT for Enhancing Drug Trafficking Detection on Social Media [PDF]
arXiv, 2023 Social media platforms such as Instagram and Twitter have emerged as critical channels for drug marketing and illegal sale. Detecting and labeling online illicit drug trafficking activities becomes important in addressing this issue. However, the effectiveness of conventional supervised learning methods in detecting drug trafficking heavily relies on ...
arxiv
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography [PDF]
arXiv, 2022 We demonstrate label-free drug response evaluations of human breast (MCF-7) and colon (HT-29) cancer spheroids via dynamic optical coherence tomography (OCT). The MCF-7 and HT-29 spheroids were treated with paclitaxel (PTX, or Taxol) and the active metabolite of irinotecan (SN-38), respectively.
arxiv
Cloned Meat, Voluntary Food Labeling, and Organic Oreos [PDF]
, 2009 [Excerpt] “In December 2006, the Food and Drug Administration (FDA) announced that it had reviewed all the available evidence and was poised to approve meat and milk from cloned animals and their progeny. I remember telling one of my colleagues, a patent
Byrne, Donna M.
core +2 more sources